Title |
Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats
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Published in |
BMC Complementary Medicine and Therapies, December 2014
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DOI | 10.1186/1472-6882-14-471 |
Pubmed ID | |
Authors |
Ji-Hye Lee, Dong Xing Li, Heera Yoon, Donghyun Go, Fu Shi Quan, Byung-Il Min, Sun Kwang Kim |
Abstract |
Oxaliplatin, an important chemotherapy drug for advanced colorectal cancer, often induces peripheral neuropathy, especially cold allodynia. Our previous study showed that bee venom acupuncture (BVA), which has been traditionally used in Korea to treat various pain symptoms, potently relieves oxaliplatin-induced cold allodynia in rats. However, the mechanism for this anti-allodynic effect of BVA remains poorly understood. We investigated whether and how the central serotonergic system, a well-known pathway for acupuncture analgesia, mediates the relieving effect of BVA on cold allodynia in oxaliplatin-injected rats. |
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