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NMP-7 Inhibits Chronic Inflammatory and Neuropathic Pain via Block of Cav3.2 T-type Calcium Channels and Activation of CB2 Receptors

Overview of attention for article published in Molecular Pain, January 2014
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Title
NMP-7 Inhibits Chronic Inflammatory and Neuropathic Pain via Block of Cav3.2 T-type Calcium Channels and Activation of CB2 Receptors
Published in
Molecular Pain, January 2014
DOI 10.1186/1744-8069-10-77
Pubmed ID
Authors

N Daniel Berger, Vinicius M Gadotti, Ravil R Petrov, Kevin Chapman, Philippe Diaz, Gerald W Zamponi

Abstract

T-type calcium channels and cannabinoid receptors are known to play important roles in chronic pain, making them attractive therapeutic targets. We recently reported on the design, synthesis and analgesic properties of a novel T-type channel inhibitor (NMP-7), which also shows mixed agonist activity on CB1 and CB2 receptors in vitro. Here, we analyzed the analgesic effect of systemically delivered NMP-7 (intraperitoneal (i.p.) or intragstric (i.g.) routes) on mechanical hypersensitivity in inflammatory pain induced by Complete Freund's Adjuvant (CFA) and neuropathic pain induced by sciatic nerve injury.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 55 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 18%
Student > Ph. D. Student 8 14%
Researcher 7 12%
Student > Master 7 12%
Other 5 9%
Other 11 19%
Unknown 9 16%
Readers by discipline Count As %
Medicine and Dentistry 10 18%
Neuroscience 9 16%
Agricultural and Biological Sciences 6 11%
Biochemistry, Genetics and Molecular Biology 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 10 18%
Unknown 15 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2015.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Molecular Pain
#477
of 669 outputs
Outputs of similar age
#243,193
of 319,281 outputs
Outputs of similar age from Molecular Pain
#35
of 58 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,281 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.