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Epidemiological trends and outcomes of extensively drug-resistant tuberculosis in Shandong, China

Overview of attention for article published in BMC Infectious Diseases, August 2017
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Title
Epidemiological trends and outcomes of extensively drug-resistant tuberculosis in Shandong, China
Published in
BMC Infectious Diseases, August 2017
DOI 10.1186/s12879-017-2652-x
Pubmed ID
Authors

Xiao-chun He, Ning-ning Tao, Yao Liu, Xian-xin Zhang, Huai-chen Li

Abstract

Extensively Drug-Resistant (XDR) Tuberculosis (TB) has posed a great threat to global health and finance systems, especially for developing countries with high TB and Multidrug-Resistant (MDR) TB burden. We retrospectively analyzed HIV-uninfected TB case confirmed and treated in Shandong Provincial Chest Hospital (SPCH) between January 2008 and December 2015. Unique characteristics of XDR-TB were identified; its longitudinal changes and survival were analyzed. Between January 2008 and December 2015, a total of 144 cases were confirmed to be XDR-TB (2.5% of 5663 culture-confirmed TB cases; 27.9% of 516 MDR-TB cases). The proportion of XDR TB cases among MDR-TB cases has increased from 26.5% in 2008 to 44.5% in 2014 (Chi-Square test for trends: P < 0.01). Among the 144 XDR-TB cases, 21 patients (14.6%) had treatment success, 123 (85.1%) had poor treatment outcomes. Mortality was higher among XDR-TB cases than among MDR TB cases (8.3% vs. 3.8%, P = 0.033) and drug-susceptible TB cases (8.3% vs. 2.1%, P < 0.01). XDR-TB cases comprise a substantial and increasing fraction of MDR-TB cases, causing poor treatment outcomes and high mortalities. Early drug susceptibility testing, adequate TB treatment and efficient infection control must be in place in future TB control strategies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 13%
Other 7 9%
Student > Ph. D. Student 6 8%
Student > Bachelor 6 8%
Researcher 5 7%
Other 16 21%
Unknown 26 34%
Readers by discipline Count As %
Medicine and Dentistry 21 28%
Immunology and Microbiology 6 8%
Nursing and Health Professions 6 8%
Veterinary Science and Veterinary Medicine 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 7 9%
Unknown 32 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2017.
All research outputs
#20,453,782
of 23,009,818 outputs
Outputs from BMC Infectious Diseases
#6,519
of 7,722 outputs
Outputs of similar age
#277,420
of 317,986 outputs
Outputs of similar age from BMC Infectious Diseases
#137
of 163 outputs
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