Title |
Randomized control trial to evaluate the effects of acute testosterone administration in men on muscle mass, strength, and physical function following ACL reconstructive surgery: rationale, design, methods
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Published in |
BMC Surgery, December 2014
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DOI | 10.1186/1471-2482-14-102 |
Pubmed ID | |
Authors |
Brian W Wu, Max Berger, Jonathan C Sum, George F Hatch, E Todd Schroeder |
Abstract |
The anterior cruciate ligament (ACL) is one of four major ligaments in the knee that provide stability during physical activity. A tear in the ACL is characterized by joint instability that leads to decreased activity, knee dysfunction, reduced quality of life and a loss of muscle mass and strength. While rehabilitation is the standard-of-care for return to daily function, additional surgical reconstruction can provide individuals with an opportunity to return to sports and strenuous physical activity. Over 200,000 ACL reconstructions are performed in the United States each year, and rehabilitation following surgery is slow and expensive. One possible method to improve the recovery process is the use of intramuscular testosterone, which has been shown to increase muscle mass and strength independent of exercise. With short-term use of supraphysiologic doses of testosterone, we hope to reduce loss of muscle mass and strength and minimize loss of physical function following ACL reconstruction compared to standard-of-care alone. |
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Pakistan | 1 | <1% |
Germany | 1 | <1% |
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Science communicators (journalists, bloggers, editors) | 1 | <1% |
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Mendeley readers
Geographical breakdown
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Researcher | 15 | 7% |
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Unknown | 66 | 29% |
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Biochemistry, Genetics and Molecular Biology | 4 | 2% |
Other | 10 | 4% |
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