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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study
|
|---|---|
| Published in |
Genes & Nutrition, December 2014
|
| DOI | 10.1007/s12263-014-0447-x |
| Pubmed ID | |
| Authors |
Raul Zamora-Ros, Nitin Shivappa, Susan E. Steck, Federico Canzian, Stefano Landi, M. Henar Alonso, James R. Hébert, Victor Moreno |
| Abstract |
Chronic inflammation is an important factor in colorectal carcinogenesis. However, evidence on the effect of pro-inflammatory and anti-inflammatory foods and nutrients is scarce. Moreover, there are few studies focusing on diet-gene interactions on inflammation and colorectal cancer (CRC). This study was designed to investigate the association between the novel dietary inflammatory index (DII) and CRC and its potential interaction with polymorphisms in inflammatory genes. Data from the Bellvitge Colorectal Cancer Study, a case-control study (424 cases with incident colorectal cancer and 401 hospital-based controls), were used. The DII score for each participant was obtained by multiplying intakes of dietary components from a validated dietary history questionnaire by literature-based dietary inflammatory weights that reflected the inflammatory potential of components. Data from four important single nucleotide polymorphisms located in genes thought to be important in inflammation-associated CRC: i.e., interleukin (IL)-4, IL-6, IL-8, and peroxisome proliferator-activated receptor-γ (PPARG) were analyzed. A direct association was observed between DII score and CRC risk (ORQ4 vs. Q1 1.65, 95 % CI 1.05-2.60, and P trend 0.011). A stronger association was found with colon cancer risk (ORQ4 vs. Q1 2.24, 95 % CI 1.33-3.77, and P trend 0.002) than rectal cancer risk (ORQ4 vs. Q1 1.12, 95 % CI 0.61-2.06, and P trend 0.37). DII score was inversely correlated with SNP rs2243250 in IL-4 among controls, and an interaction was observed with CRC risk. Neither correlation nor interaction was detected for other inflammatory genes. Overall, high-DII diets are associated with increased risk of CRC, particularly for colon cancer, suggesting that dietary-mediated inflammation plays an important role in colorectal carcinogenesis. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 29% |
| Germany | 1 | 14% |
| Venezuela, Bolivarian Republic of | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 1% |
| Netherlands | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 130 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 13% |
| Student > Bachelor | 15 | 11% |
| Researcher | 11 | 8% |
| Student > Doctoral Student | 10 | 7% |
| Other | 7 | 5% |
| Other | 20 | 15% |
| Unknown | 54 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 34% |
| Nursing and Health Professions | 9 | 7% |
| Biochemistry, Genetics and Molecular Biology | 8 | 6% |
| Agricultural and Biological Sciences | 6 | 4% |
| Social Sciences | 2 | 1% |
| Other | 7 | 5% |
| Unknown | 56 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2016.
All research outputs
#3,634,777
of 22,772,779 outputs
Outputs from Genes & Nutrition
#70
of 388 outputs
Outputs of similar age
#52,834
of 361,040 outputs
Outputs of similar age from Genes & Nutrition
#3
of 15 outputs
Altmetric has tracked 22,772,779 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 388 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,040 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.