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Mendeley readers
Attention Score in Context
| Title |
MiRNAs regulate oxidative stress related genes via binding to the 3′ UTR and TATA-box regions: a new hypothesis for cataract pathogenesis
|
|---|---|
| Published in |
BMC Ophthalmology, August 2017
|
| DOI | 10.1186/s12886-017-0537-9 |
| Pubmed ID | |
| Authors |
Changrui Wu, Zhao Liu, Le Ma, Cheng Pei, Li Qin, Ning Gao, Jun Li, Yue Yin |
| Abstract |
Age-related cataracts are related to oxidative stress. However, the genome-wide screening of cataract related oxidative stress related genes are not thoroughly investigated. Our study aims to identify cataract regulated miRNA target genes that are related to oxidative stress and to propose a new possible mechanism for cataract formation. Microarrays were used to determine the mRNA expression profiles of both transparent and cataractous lenses. The results were analyzed by significance analyses performed by the microarray software, and bioinformatics analysis was further conducted using Molecular Annotation System. The Eukaryotic Promoter Database (EPD) was used to retrieve promoter sequences and identify TATA-box motifs. Online resource miRWalk was exploited to screen for validated miRNAs targeting mRNAs related to oxidative stress. RNAhybrid online tool was applied to predict the binding between significantly regulated miRNAs in cataract lenses and target mRNAs. Oxidative stress pathway was significantly regulated in cataractous lens samples. Pro-oxidative genes were half up-regulated (11/20), with a small number of genes down-regulated (4/20) and the rest of them with no significant change (5/20). Anti-oxidative genes were partly up-regulated (17/69) and partly down-regulated (17/69). Four down-regulated miRNAs (has-miR-1207-5p, has-miR-124-3p, has-miR-204-3p, has-miR-204-5p) were found to target 3' UTR of pro-oxidative genes and could also bind to the TATA-box regions of anti-oxidative genes (with the exception of has-miR-204-3p), whilst two up-regulated miRNAs (has-miR-222-3p, has-miR-378a-3p) were found to target 3' UTR of anti-oxidative genes and could simultaneously bind to the TATA-box regions of pro-oxidative genes. We propose for the first time a hypothesis that cataract regulated miRNAs could contribute to cataract formation not only by targeting 3' UTR but also by targeting TATA-box region of oxidative stress related genes. This results in the subsequent elevation of pro-oxidative genes and inhibition of anti-oxidative genes. This miRNA-TATA-box/3' UTR-gene-regulation network may contribute to cataract pathogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 18% |
| Student > Ph. D. Student | 2 | 18% |
| Student > Doctoral Student | 2 | 18% |
| Lecturer > Senior Lecturer | 1 | 9% |
| Student > Bachelor | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 2 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 27% |
| Unspecified | 2 | 18% |
| Agricultural and Biological Sciences | 2 | 18% |
| Biochemistry, Genetics and Molecular Biology | 1 | 9% |
| Nursing and Health Professions | 1 | 9% |
| Other | 0 | 0% |
| Unknown | 2 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2020.
All research outputs
#7,542,164
of 23,009,818 outputs
Outputs from BMC Ophthalmology
#366
of 2,401 outputs
Outputs of similar age
#120,602
of 317,653 outputs
Outputs of similar age from BMC Ophthalmology
#3
of 27 outputs
Altmetric has tracked 23,009,818 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,401 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,653 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.