Title |
New variant identified in major susceptibility locus to tuberculosis on chromosomal region 8q12-q13 in Moroccan population: a case control study
|
---|---|
Published in |
BMC Infectious Diseases, November 2017
|
DOI | 10.1186/s12879-017-2807-9 |
Pubmed ID | |
Authors |
Mounia Qrafli, Imane Asekkaj, Jamal Eddine Bourkadi, Rajae El Aouad, Khalid Sadki |
Abstract |
Tuberculosis (TB) remains a global health problem. Several studies have implicated genetic host factors in predisposing populations to TB disease. In this study, we have selected NSMAF (Neutral Sphingomyelinase Activation Associated Factor) as a candidate gene to evaluate its level of association with TB disease in a Moroccan population for two reasons: first, this gene is located in a major susceptibility locus on chromosomal region 8q12-q13 in the Moroccan population, closely linked to the CYP7A1 gene, which was previously shown to be associated with TB disease; second, NSMAF has an important role in immune system function. We conducted a case-control study including 269 genomic DNA samples extracted from pulmonary TB (PTB) patients and healthy controls (HC). We genotyped three selected SNPs (rs2228505, rs36067275 and rs10505004) using TaqMan® allelic discrimination assays. Only the rs1050504 C > T genotype was observed to be significantly associated with an increased risk for developing pulmonary TB (41.8% vs 27%, OR 1.95, 95% CI 1.16-3.27; p = 0.01). In contrast, the TT genotype was significantly associated with resistance to PTB (4.1% vs 15.6%, OR 0.23, 95% CI 0.08-0.63; p = 0.002). Our findings suggest that genetic variations in the NSMAF gene could modulate the risk of PTB development in a Moroccan population. Further functional studies are needed to confirm these findings. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 18% |
Student > Bachelor | 2 | 9% |
Student > Master | 2 | 9% |
Student > Doctoral Student | 1 | 5% |
Lecturer | 1 | 5% |
Other | 4 | 18% |
Unknown | 8 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 4 | 18% |
Nursing and Health Professions | 3 | 14% |
Medicine and Dentistry | 2 | 9% |
Arts and Humanities | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 3 | 14% |
Unknown | 8 | 36% |