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A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization

Overview of attention for article published in BMC Bioinformatics, June 2010
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

twitter
1 X user
wikipedia
1 Wikipedia page

Citations

dimensions_citation
44 Dimensions

Readers on

mendeley
102 Mendeley
citeulike
2 CiteULike
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Title
A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization
Published in
BMC Bioinformatics, June 2010
DOI 10.1186/1471-2105-11-316
Pubmed ID
Authors

Eelke van der Horst, Julio E Peironcely, Adriaan P IJzerman, Margot W Beukers, Jonathan R Lane, Herman WT van Vlijmen, Michael TM Emmerich, Yasushi Okuno, Andreas Bender

Abstract

G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets with significant therapeutic value. Phylogenetic classifications may help to understand the characteristics of individual GPCRs and their subtypes. Previous phylogenetic classifications were all based on the sequences of receptors, adding only minor information about the ligand binding properties of the receptors. In this work, we compare a sequence-based classification of receptors to a ligand-based classification of the same group of receptors, and evaluate the potential to use sequence relatedness as a predictor for ligand interactions thus aiding the quest for ligands of orphan receptors.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 5%
France 2 2%
Netherlands 1 <1%
Sweden 1 <1%
Denmark 1 <1%
Spain 1 <1%
Japan 1 <1%
Unknown 90 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 28 27%
Student > Ph. D. Student 26 25%
Student > Master 13 13%
Professor > Associate Professor 8 8%
Student > Bachelor 7 7%
Other 12 12%
Unknown 8 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 30%
Chemistry 22 22%
Biochemistry, Genetics and Molecular Biology 14 14%
Medicine and Dentistry 7 7%
Computer Science 6 6%
Other 13 13%
Unknown 9 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2021.
All research outputs
#7,204,796
of 22,774,233 outputs
Outputs from BMC Bioinformatics
#2,859
of 7,276 outputs
Outputs of similar age
#33,242
of 96,083 outputs
Outputs of similar age from BMC Bioinformatics
#34
of 77 outputs
Altmetric has tracked 22,774,233 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 7,276 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,083 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.