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Attention Score in Context
| Title |
Genomic locus on chromosome 1 regulates susceptibility to spontaneous arthritis in mice deficiency of IL-1RA
|
|---|---|
| Published in |
BMC Immunology, December 2014
|
| DOI | 10.1186/s12865-014-0057-9 |
| Pubmed ID | |
| Authors |
Nan Deng, Yan Jiao, Yanhong Cao, Xiaoyun Liu, Yonghui Ma, Karen A Hasty, David D Brand, John M Stuart, Weikuan Gu |
| Abstract |
BackgroundTo understand the role of genetic factors on chromosome 1 in the regulation of spontaneous arthritis in mice deficient in IL-1 receptor antagonist protein (IL_1RA), we previously used speed congenic breeding to transfer the QTL region from DBA/1¿/¿ mice that are resistant to spontaneous arthritis into BALB/c¿/¿ mice which are susceptible. We were able to establish two congenic strains which exhibited a delayed onset and reduced severity of disease. In this study, we asked a different set of questions. How will the QTL region from BALB/c¿/¿ interact with the rest of the genome in the DBA/1¿/¿ background? Will the DBA/1¿/¿ mice become susceptible to spontaneous arthritis if the QTL genomic region on chromosome 1 was replaced with the genomic fragment of the same region from BALB/c¿/¿? We conducted the congenic breeding with the similar procedure as that of congenic strains with BALB/c¿/¿ background.ResultInstead of BALB/c¿/¿, DBA/1¿/¿ was used as the recurrent parent while BALB/c¿/¿ was used as the donor parent. By the 6th generation we determined that all of the chromosomes in the progeny were of DBA/1¿/¿ origin with the exception of the QTL portion of chromosome 1 which is heterozygous of BALB/c¿/¿ and DBA/1¿/¿ origin. We then intercrossed selected mice to produce homozygous strains containing the homozygous genomic region of BALB/c¿/¿ on chromosome 1, while the rest of genome are homozygous DBA/1¿/¿. This strain was observed for the development of spontaneous arthritis. Up to 9 weeks of age, both congenic strain and DBA/1¿/¿ did not develop arthritis. However, after 9 weeks, the congenic strain started to exhibit signs of arthritis, while the DBA/1¿/¿ remained free from disease.ConclusionThe result indicates a strong influence of genetic factor(s) on the QTL of chromosome 1 on the susceptibility to spontaneous arthritis. Identification of genetic factors within this QTL region in the future will significantly enhance our understanding of molecular mechanism of spontaneous arthritis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 1 | 20% |
| Student > Doctoral Student | 1 | 20% |
| Student > Bachelor | 1 | 20% |
| Student > Master | 1 | 20% |
| Professor > Associate Professor | 1 | 20% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 40% |
| Agricultural and Biological Sciences | 1 | 20% |
| Immunology and Microbiology | 1 | 20% |
| Engineering | 1 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2014.
All research outputs
#18,386,678
of 22,774,233 outputs
Outputs from BMC Immunology
#421
of 585 outputs
Outputs of similar age
#261,452
of 361,040 outputs
Outputs of similar age from BMC Immunology
#10
of 13 outputs
Altmetric has tracked 22,774,233 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 585 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.