Title |
Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus
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Published in |
Fluids and Barriers of the CNS, March 2012
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DOI | 10.1186/2045-8118-9-7 |
Pubmed ID | |
Authors |
Sunil Patel, Edward B Lee, Sharon X Xie, Anica Law, Eric M Jackson, Steven E Arnold, Christopher M Clark, Leslie M Shaw, M Sean Grady, John Q Trojanowski, Roy H Hamilton |
Abstract |
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible cause of dementia and gait disturbance that is typically treated by operative placement of a ventriculoperitoneal shunt. The outcome from shunting is variable, and some evidence suggests that the presence of comorbid Alzheimer's disease (AD) may impact shunt outcome. Evidence also suggests that AD biomarkers in cerebrospinal fluid (CSF) may predict the presence of AD. The aim of this study was to investigate the relationship between the phosphorylated tau/amyloid beta 1-42 (ptau/Aβ1-42) ratio in ventricular CSF and shunt outcome in patients with iNPH. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 3% |
Netherlands | 1 | 2% |
Germany | 1 | 2% |
United Kingdom | 1 | 2% |
Australia | 1 | 2% |
Unknown | 59 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 17% |
Student > Ph. D. Student | 8 | 12% |
Student > Postgraduate | 7 | 11% |
Other | 6 | 9% |
Student > Bachelor | 5 | 8% |
Other | 15 | 23% |
Unknown | 13 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 38% |
Neuroscience | 9 | 14% |
Agricultural and Biological Sciences | 4 | 6% |
Psychology | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 4 | 6% |
Unknown | 18 | 28% |