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Incomplete evidence: the inadequacy of databases in tracing published adverse drug reactions in clinical trials

Overview of attention for article published in BMC Medical Research Methodology, September 2001
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Title
Incomplete evidence: the inadequacy of databases in tracing published adverse drug reactions in clinical trials
Published in
BMC Medical Research Methodology, September 2001
DOI 10.1186/1471-2288-1-7
Pubmed ID
Authors

Sheena Derry, Yoon Kong Loke, Jeffrey K Aronson

Abstract

We would expect information on adverse drug reactions in randomised clinical trials to be easily retrievable from specific searches of electronic databases. However, complete retrieval of such information may not be straightforward, for two reasons. First, not all clinical drug trials provide data on the frequency of adverse effects. Secondly, not all electronic records of trials include terms in the abstract or indexing fields that enable us to select those with adverse effects data. We have determined how often automated search methods, using indexing terms and/or textwords in the title or abstract, would fail to retrieve trials with adverse effects data.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 4%
Germany 1 2%
Canada 1 2%
Unknown 45 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 27%
Librarian 7 14%
Student > Ph. D. Student 7 14%
Student > Master 4 8%
Student > Postgraduate 3 6%
Other 8 16%
Unknown 7 14%
Readers by discipline Count As %
Medicine and Dentistry 23 47%
Economics, Econometrics and Finance 4 8%
Social Sciences 3 6%
Mathematics 1 2%
Agricultural and Biological Sciences 1 2%
Other 5 10%
Unknown 12 24%