Title |
Prediction of methotrexate efficacy and adverse events in patients with juvenile idiopathic arthritis: a systematic literature review
|
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Published in |
Pediatric Rheumatology, December 2014
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DOI | 10.1186/1546-0096-12-51 |
Pubmed ID | |
Authors |
EH Pieter van Dijkhuizen, Nico M Wulffraat |
Abstract |
Methotrexate (MTX) is the cornerstone disease-modifying anti-rheumatic drug in juvenile idiopathic arthritis (JIA). In JIA, it is important to start effective treatment early to avoid long-term sequelae, such as joint damage. To accomplish this goal, it is crucial to know beforehand who is going to respond well to MTX. In addition, MTX adverse effects such as MTX intolerance occur frequently, potentially hindering its efficacy. To avoid inefficacy of an otherwise effective drug, the physician should be timely aware of these adverse events. Consequently, to optimise treatment of JIA patients with MTX, predictors for efficacy and adverse events should be used in daily clinical practice. The aim of this study was to summarise the existing knowledge about such predictors. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 20% |
El Salvador | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Singapore | 1 | 1% |
South Africa | 1 | 1% |
Canada | 1 | 1% |
Unknown | 72 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 19% |
Researcher | 9 | 12% |
Student > Bachelor | 9 | 12% |
Other | 8 | 11% |
Student > Master | 8 | 11% |
Other | 15 | 20% |
Unknown | 12 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 40 | 53% |
Agricultural and Biological Sciences | 7 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Psychology | 3 | 4% |
Other | 4 | 5% |
Unknown | 13 | 17% |