Title |
The involvement of miR-100 in bladder urothelial carcinogenesis changing the expression levels of mRNA and proteins of genes related to cell proliferation, survival, apoptosis and chromosomal stability
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Published in |
Cancer Cell International, November 2014
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DOI | 10.1186/s12935-014-0119-3 |
Pubmed ID | |
Authors |
Denis R Morais, Sabrina T Reis, Nayara Viana, Camila Berfort Piantino, Cristina Massoco, Caio Moura, Nelson Dip, Iran A Silva, Miguel Srougi, Katia RM Leite |
Abstract |
MicroRNAs (miRNA) are small non-coding RNAs that play an important role in the control of gene expression by inhibiting protein translation or promoting messenger RNA degradation. Today, miRNAs have been shown to be involved in various physiological and pathological cellular processes, including cancer, where they can act as oncogenes or tumor suppressor genes. Recently, lowered expression of miR-100, resulting in upregulation of FGFR3, has been correlated with low-grade, non-invasive bladder urothelial cancer, as an alternative oncogenesis pathway to the typical FGFR3 gene mutation. Our aim is to analyze the role of miR-100 in bladder cancer cell lines in controlling the expression of some of its possible target genes, including FGFR3 and its relationship with proliferation, apoptosis and DNA ploidy. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 35% |
Researcher | 5 | 29% |
Professor | 1 | 6% |
Student > Doctoral Student | 1 | 6% |
Professor > Associate Professor | 1 | 6% |
Other | 0 | 0% |
Unknown | 3 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 41% |
Agricultural and Biological Sciences | 3 | 18% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Veterinary Science and Veterinary Medicine | 1 | 6% |
Environmental Science | 1 | 6% |
Other | 1 | 6% |
Unknown | 3 | 18% |