Title |
Human mesenchymal stem cells possess different biological characteristics but do not change their therapeutic potential when cultured in serum free medium
|
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Published in |
Stem Cell Research & Therapy, December 2014
|
DOI | 10.1186/scrt522 |
Pubmed ID | |
Authors |
Youwei Wang, Hehe Wu, Zhouxin Yang, Ying Chi, Lei Meng, Aibin Mao, Shulin Yan, Shanshan Hu, Jianzhong Zhang, Yun Zhang, Wenbo Yu, Yue Ma, Tao Li, Yan Cheng, Yongjuan Wang, Shanshan Wang, Jing Liu, Jingwen Han, Caiyun Li, Li Liu, Jian Xu, Zhi Bo Han, Zhong Chao Han |
Abstract |
Mesenchymal stem cells (MSCs) are widely investigated in clinical researches to treat various diseases. Classic culture medium for MSCs, even for clinical use, contains fetal bovine serum. The serum-containing medium (SCM) seems a major obstacle for MSCs-related therapies due to the risk of contamination of infectious pathogens. Some studies showed that MSCs could be expanded in serum free medium (SFM); however, whether SFM would change the biological characteristics and safety issues of MSCs has not been well answered. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Russia | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 4% |
United Kingdom | 1 | 2% |
Poland | 1 | 2% |
Unknown | 52 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 27% |
Researcher | 12 | 21% |
Student > Master | 7 | 13% |
Student > Bachelor | 4 | 7% |
Student > Postgraduate | 4 | 7% |
Other | 3 | 5% |
Unknown | 11 | 20% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 12 | 21% |
Biochemistry, Genetics and Molecular Biology | 11 | 20% |
Medicine and Dentistry | 9 | 16% |
Engineering | 4 | 7% |
Chemical Engineering | 3 | 5% |
Other | 7 | 13% |
Unknown | 10 | 18% |