Title |
Pilot study: bone marrow stem cells as a treatment for dogs with chronic spinal cord injury
|
---|---|
Published in |
Regenerative Medicine Research, December 2014
|
DOI | 10.1186/2050-490x-2-9 |
Pubmed ID | |
Authors |
Carlos Alberto Palmeira Sarmento, Marcio Nogueira Rodrigues, Renato Zonzini Bocabello, Andrea Maria Mess, Maria Angelica Miglino |
Abstract |
Chronic Spinal Cord injury is a common, severe, and medically untreatable disease. Since the functional outcomes of acute and experimental chronic spinal cord injury have been shown to improve with stem cell therapy, a case study was conducted to test if the application of stem cell also regenerates chronic SCI dysfunction. Transplantation of foetal bone marrow stem cells was applied in seven dogs with chronic spinal cord injury. Magnetic resonance images and assessments of symptoms according to the Olby scale were used to diagnose the severity of injury. All dogs improved locomotor and sensory function when examined 90 days after surgery, and showed increased movement of the hind limbs, and were able to stand upright, as well as to take small steps. Tail tone was observed in seven dogs, pain reflexes and defecation return were observed in five dogs. The transplantation of bone marrow stem may be a promising, reliable and safe treatment for chronic spinal cord injury. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 20% |
United States | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 2 | 3% |
Unknown | 61 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 16% |
Student > Master | 9 | 14% |
Student > Bachelor | 8 | 13% |
Student > Ph. D. Student | 6 | 10% |
Student > Doctoral Student | 6 | 10% |
Other | 13 | 21% |
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Neuroscience | 6 | 10% |
Nursing and Health Professions | 3 | 5% |
Other | 6 | 10% |
Unknown | 14 | 22% |