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PfRON3 is an erythrocyte-binding protein and a potential blood-stage vaccine candidate antigen

Overview of attention for article published in Malaria Journal, December 2014
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Mentioned by

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2 tweeters

Citations

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9 Dimensions

Readers on

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36 Mendeley
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Title
PfRON3 is an erythrocyte-binding protein and a potential blood-stage vaccine candidate antigen
Published in
Malaria Journal, December 2014
DOI 10.1186/1475-2875-13-490
Pubmed ID
Authors

Xin Zhao, Zhiguang Chang, Zhiwei Tu, Shengchao Yu, Xiaoyan Wei, Jianhua Zhou, Huijun Lu, Ning Jiang, Qijun Chen

Abstract

Erythrocyte invasion by merozoites is an essential step in Plasmodium falciparum infection and leads to subsequent disease pathology. Proteins both on the merozoite surface and secreted from the apical organelles (micronemes, rhoptries and dense granules) mediate the invasion of erythrocytes; some of the molecules have been regarded as targets in the development of an anti-malaria vaccine. Recently, a subgroup of rhoptry neck proteins (PfRON2, PfRON4 and PfRON5) associated with the microneme protein apical membrane antigen AMA1 has been described as components of the moving junction complex that assists merozoite invasion into erythrocytes. However, unlike PfRON2, PfRON4 and PfRON5, the latest study suggested that PfRON3 might be located in the rhoptry bulb and participates in a novel PfRON complex (PfRON2, 3 and 4), but does not form a complex with AMA1. Additionally, the full-length PfRON3 protein possesses three transmembrane regions at the N-terminus, which is highly conserved among RON3 orthologues in the genus Plasmodium, Toxoplasma gondii and Eimeria tenella. Overall, these findings suggest that PfRON3 may play an important role in merozoite invasion into erythrocytes.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 28%
Student > Master 7 19%
Researcher 6 17%
Student > Bachelor 5 14%
Lecturer > Senior Lecturer 2 6%
Other 6 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 31%
Medicine and Dentistry 8 22%
Biochemistry, Genetics and Molecular Biology 5 14%
Veterinary Science and Veterinary Medicine 3 8%
Nursing and Health Professions 2 6%
Other 6 17%
Unknown 1 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2015.
All research outputs
#3,411,216
of 5,165,050 outputs
Outputs from Malaria Journal
#1,485
of 2,063 outputs
Outputs of similar age
#112,035
of 180,302 outputs
Outputs of similar age from Malaria Journal
#62
of 94 outputs
Altmetric has tracked 5,165,050 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,063 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,302 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.