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PPARα is essential for retinal lipid metabolism and neuronal survival

Overview of attention for article published in BMC Biology, November 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

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13 tweeters

Citations

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25 Dimensions

Readers on

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42 Mendeley
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Title
PPARα is essential for retinal lipid metabolism and neuronal survival
Published in
BMC Biology, November 2017
DOI 10.1186/s12915-017-0451-x
Pubmed ID
Authors

Elizabeth A. Pearsall, Rui Cheng, Kelu Zhou, Yusuke Takahashi, H. Greg Matlock, Shraddha S. Vadvalkar, Younghwa Shin, Thomas W. Fredrick, Marin L. Gantner, Steven Meng, Zhongjie Fu, Yan Gong, Michael Kinter, Kenneth M. Humphries, Luke I. Szweda, Lois E. H. Smith, Jian-xing Ma

Abstract

Peroxisome proliferator activated receptor-alpha (PPARα) is a ubiquitously expressed nuclear receptor. The role of endogenous PPARα in retinal neuronal homeostasis is unknown. Retinal photoreceptors are the highest energy-consuming cells in the body, requiring abundant energy substrates. PPARα is a known regulator of lipid metabolism, and we hypothesized that it may regulate lipid use for oxidative phosphorylation in energetically demanding retinal neurons. We found that endogenous PPARα is essential for the maintenance and survival of retinal neurons, with Pparα -/- mice developing retinal degeneration first detected at 8 weeks of age. Using extracellular flux analysis, we identified that PPARα mediates retinal utilization of lipids as an energy substrate, and that ablation of PPARα ultimately results in retinal bioenergetic deficiency and neurodegeneration. This may be due to PPARα regulation of lipid transporters, which facilitate the internalization of fatty acids into cell membranes and mitochondria for oxidation and ATP production. We identify an endogenous role for PPARα in retinal neuronal survival and lipid metabolism, and furthermore underscore the importance of fatty acid oxidation in photoreceptor survival. We also suggest PPARα as a putative therapeutic target for age-related macular degeneration, which may be due in part to decreased mitochondrial efficiency and subsequent energetic deficits.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 26%
Researcher 6 14%
Student > Bachelor 5 12%
Student > Master 5 12%
Professor 3 7%
Other 5 12%
Unknown 7 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 24%
Biochemistry, Genetics and Molecular Biology 8 19%
Medicine and Dentistry 4 10%
Neuroscience 4 10%
Engineering 2 5%
Other 5 12%
Unknown 9 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2022.
All research outputs
#4,054,419
of 20,110,162 outputs
Outputs from BMC Biology
#973
of 1,721 outputs
Outputs of similar age
#107,674
of 435,977 outputs
Outputs of similar age from BMC Biology
#95
of 127 outputs
Altmetric has tracked 20,110,162 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,721 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 435,977 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.