Title |
Deficient nitric oxide signalling impairs skeletal muscle growth and performance: involvement of mitochondrial dysregulation
|
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Published in |
Skeletal Muscle, December 2014
|
DOI | 10.1186/s13395-014-0022-6 |
Pubmed ID | |
Authors |
Clara De Palma, Federica Morisi, Sarah Pambianco, Emma Assi, Thierry Touvier, Stefania Russo, Cristiana Perrotta, Vanina Romanello, Silvia Carnio, Valentina Cappello, Paolo Pellegrino, Claudia Moscheni, Maria Teresa Bassi, Marco Sandri, Davide Cervia, Emilio Clementi |
Abstract |
Nitric oxide (NO), generated in skeletal muscle mostly by the neuronal NO synthases (nNOSμ), has profound effects on both mitochondrial bioenergetics and muscle development and function. The importance of NO for muscle repair emerges from the observation that nNOS signalling is defective in many genetically diverse skeletal muscle diseases in which muscle repair is dysregulated. How the effects of NO/nNOSμ on mitochondria impact on muscle function, however, has not been investigated yet. |
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Geographical breakdown
Country | Count | As % |
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United States | 8 | 38% |
United Kingdom | 4 | 19% |
France | 1 | 5% |
Finland | 1 | 5% |
Belgium | 1 | 5% |
Unknown | 6 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 48% |
Scientists | 6 | 29% |
Practitioners (doctors, other healthcare professionals) | 4 | 19% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Germany | 1 | 1% |
Brazil | 1 | 1% |
Italy | 1 | 1% |
South Africa | 1 | 1% |
United States | 1 | 1% |
Unknown | 83 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 21% |
Researcher | 14 | 16% |
Student > Bachelor | 14 | 16% |
Student > Master | 10 | 11% |
Other | 8 | 9% |
Other | 14 | 16% |
Unknown | 11 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 19 | 21% |
Medicine and Dentistry | 15 | 17% |
Agricultural and Biological Sciences | 13 | 14% |
Sports and Recreations | 12 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Other | 12 | 13% |
Unknown | 14 | 16% |