Title |
Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes
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Published in |
Journal of Neuroinflammation, February 2007
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DOI | 10.1186/1742-2094-4-8 |
Pubmed ID | |
Authors |
Perdita L Pugh, Martin P Vidgeon-Hart, Tracey Ashmeade, Ainsley A Culbert, Zoe Seymour, Marion J Perren, Flora Joyce, Simon T Bate, Anna Babin, David J Virley, Jill C Richardson, Neil Upton, David Sunter |
Abstract |
Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the main source of CNS noradrenaline (NA). The LC has projections to brain regions vulnerable to amyloid deposition and lack of LC derived NA could play a role in the progression of neuroinflammation in AD. Previous studies reveal that intraperitoneal (IP) injection of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) can modulate neuroinflammation in amyloid over-expressing mice and in one study, DSP-4 exacerbated existing neurodegeneration. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Japan | 1 | 2% |
Netherlands | 1 | 2% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 14% |
Researcher | 7 | 14% |
Professor | 5 | 10% |
Student > Bachelor | 4 | 8% |
Other | 8 | 16% |
Unknown | 8 | 16% |
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Psychology | 2 | 4% |
Other | 7 | 14% |
Unknown | 14 | 28% |