Title |
Clinical and microbiological characteristics of bloodstream infections due to AmpC β-lactamase producing Enterobacteriaceae: an active surveillance cohort in a large centralized Canadian region
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Published in |
BMC Infectious Diseases, December 2014
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DOI | 10.1186/s12879-014-0647-4 |
Pubmed ID | |
Authors |
Vikas P Chaubey, Johann D D Pitout, Bruce Dalton, Daniel B Gregson, Terry Ross, Kevin B Laupland |
Abstract |
BackgroundThe objective of this study was to describe the clinical and microbiological characteristics of bloodstream infections (BSIs) due to AmpC producing Enterobacteriaceae (AE) in a large centralized Canadian region over a 9-year period.MethodsAn active surveillance cohort design in Calgary, Canada.ResultsA cohort of 458 episodes of BSIs caused by AE was assembled for analysis. The majority of infections were of nosocomial origin with unknown sources. Enterobacter spp. was the most common species while BSIs due to Serratia spp. had a significant higher mortality when compared to other AE. Delays in empiric or definitive antibiotic therapy were not associated with a difference in outcome. However, patients that did not receive any empiric antimicrobial therapy had increased mortality (3/5; 60% vs. 57/453; 13%; p¿=¿0.018) as did those that did not receive definitive therapy (6/17; 35% vs. 54/441; 12%; p¿=¿0.015).ConclusionsDelays in therapy were not associated with adverse outcomes although lack of active therapy was associated with increased mortality. A strategy for BSIs due to AE where ß-lactam antibiotics (including oxyimino-cephalosporins) are used initially followed by a switch to non-ß-lactam antibiotics once susceptibility results are available is effective. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 15% |
Student > Doctoral Student | 6 | 13% |
Student > Postgraduate | 5 | 10% |
Researcher | 5 | 10% |
Other | 4 | 8% |
Other | 9 | 19% |
Unknown | 12 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 25 | 52% |
Immunology and Microbiology | 3 | 6% |
Agricultural and Biological Sciences | 2 | 4% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Nursing and Health Professions | 1 | 2% |
Other | 4 | 8% |
Unknown | 12 | 25% |