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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Site-specific metabolic phenotypes in metastatic breast cancer
|
|---|---|
| Published in |
Journal of Translational Medicine, December 2014
|
| DOI | 10.1186/s12967-014-0354-3 |
| Pubmed ID | |
| Authors |
Hye Min Kim, Woo Hee Jung, Ja Seung Koo |
| Abstract |
BackgroundThe purpose of this study was to examine the expression of metabolism-related proteins according to metastatic site in metastatic breast cancer and to assess the implication of site-specific differential expression.MethodsA tissue microarray containing 162 cases of metastatic breast cancer (52 lung metastasis, 47 bone metastasis, 39 brain metastasis, and 24 liver metastasis) was constructed. It was subject to immunohistochemical staining of the following proteins: Glycolysis-related: Glut-1, hexolinase II, carbonic anhydrase (CA) IX, and monocarboxylate transporter (MCT) 4; glutaminolysis-related: glutaminase (GLS) 1, glutamate dehydrogenase (GDH), and amino acid transporter (ASCT) 2; mitochondrial metabolism-related: ATP synthase, succinate dehydrogenase (SDH)A, and SDHB; and serine/glycine metabolism related: phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT), phosphoserine phosphatase (PSPH), glycine decarboxylase (GLDC), and serine hydroxymethyltransferase (SHMT).ResultsThe expression levels of glycolysis-related-proteins (Glut-1, hexokinase II, CAIX, and MCT4) differed according to metastatic site, with higher expression seen in the brain and lower expression in the bone and liver (p¿<¿0.001, 0.001, 0.009, and <0.001, respectively). Differences in metabolic phenotype were analyzed according to metastasis site. Glycolysis type was most frequently encountered in the brain and lung (p¿<¿0.001). In univariate analysis, the factors associated with shorter overall survival were CAIX positivity (p¿=¿0.044), PSPH positivity (p¿=¿0.045), and SHMT1 positivity (p¿=¿0.002), as well as serine/glycine type (p¿=¿0.041).ConclusionsDifferences in metabolic features according to metastatic site were seen in metastatic breast cancer, with the glycolysis phenotype found predominantly in the brain and lung and the non-glycolysis phenotype in the bone and liver. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 33% |
| Student > Ph. D. Student | 12 | 19% |
| Student > Bachelor | 8 | 13% |
| Student > Master | 7 | 11% |
| Unspecified | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 9 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 30% |
| Medicine and Dentistry | 12 | 19% |
| Agricultural and Biological Sciences | 12 | 19% |
| Chemistry | 4 | 6% |
| Unspecified | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 13 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2020.
All research outputs
#13,925,649
of 22,774,233 outputs
Outputs from Journal of Translational Medicine
#1,696
of 3,984 outputs
Outputs of similar age
#182,471
of 354,985 outputs
Outputs of similar age from Journal of Translational Medicine
#48
of 134 outputs
Altmetric has tracked 22,774,233 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,984 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,985 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 134 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.