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Identification of skin-expressed genes possibly associated with wool growth regulation of Aohan fine wool sheep

Overview of attention for article published in BMC Genomic Data, December 2014
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Title
Identification of skin-expressed genes possibly associated with wool growth regulation of Aohan fine wool sheep
Published in
BMC Genomic Data, December 2014
DOI 10.1186/s12863-014-0144-1
Pubmed ID
Authors

Nan Liu, Hegang Li, Kaidong Liu, Juanjuan Yu, Ran Bu, Ming Cheng, Wei De, Jifeng Liu, Guangling He, Jinshan Zhao

Abstract

BackgroundSheep are valuable resources for the animal fibre industry. Therefore, identifying genes which regulate wool growth would offer strategies for improving the quality of fine wool. In this study, we employed Agilent sheep gene expression microarray and proteomic technology to compare the gene expression patterns of the body side (hair-rich) and groin (hairless) skins of Aohan fine wool sheep (a Chinese indigenous breed).ResultsComparing the body side to the groin skins (S/G) of Aohan fine wool sheep, the microarray study revealed that 1494 probes were differentially expressed, including 602 more highly expressed and 892 less highly expressed probes. The microarray results were verified by means of quantitative PCR. Cluster analysis could distinguish the body side skin and the groin skin. Based on the Database for Annotation, Visualization and Integrated Discovery (DAVID), 38 of the differentially expressed genes were classified into four categories, namely regulation of receptor binding, multicellular organismal process, protein binding and macromolecular complex. Proteomic study revealed that 187 protein spots showed significant (p¿<¿0.05) differences in their respective expression levels. Among them, 46 protein entries were further identified by MALDI-TOF/MS analyses.ConclusionsMicroarray analysis revealed thousands of differentially expressed genes, many of which were possibly associated with wool growth. Several potential gene families might participate in hair growth regulation. Proteomic analysis also indentified hundreds of differentially expressed proteins.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 24%
Student > Ph. D. Student 3 18%
Student > Postgraduate 2 12%
Professor 1 6%
Student > Bachelor 1 6%
Other 1 6%
Unknown 5 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 47%
Biochemistry, Genetics and Molecular Biology 3 18%
Computer Science 1 6%
Unknown 5 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2014.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from BMC Genomic Data
#668
of 1,204 outputs
Outputs of similar age
#221,168
of 360,783 outputs
Outputs of similar age from BMC Genomic Data
#21
of 42 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,204 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,783 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.