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Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials

Overview of attention for article published in Trials, December 2014
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Title
Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials
Published in
Trials, December 2014
DOI 10.1186/1745-6215-15-486
Pubmed ID
Authors

Beena G Sood, Martin Keszler, Meena Garg, Jonathan M Klein, Robin Ohls, Namasivayam Ambalavanan, C Michael Cotten, Monica Malian, Pablo J Sanchez, Satyan Lakshminrusimha, Leif D Nelin, Krisa P Van Meurs, Rebecca Bara, Shampa Saha, Abhik Das, Dennis Wallace, Rosemary D Higgins, Seetha Shankaran, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Abstract

Inhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of infants. Aerosolized prostaglandins I2 (PGI2) and E1 (PGE1) have been reported to be effective selective pulmonary vasodilators. The objective of this study was to evaluate the feasibility of a randomized controlled trial (RCT) of inhaled PGE1 (IPGE1) in NHRF.

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The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 15%
Student > Master 8 12%
Student > Bachelor 8 12%
Student > Ph. D. Student 6 9%
Student > Postgraduate 6 9%
Other 11 16%
Unknown 18 27%
Readers by discipline Count As %
Medicine and Dentistry 28 42%
Nursing and Health Professions 5 7%
Biochemistry, Genetics and Molecular Biology 3 4%
Agricultural and Biological Sciences 2 3%
Computer Science 2 3%
Other 9 13%
Unknown 18 27%