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The sympathetic nervous response in inflammation

Overview of attention for article published in Arthritis Research & Therapy, December 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#35 of 2,740)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

twitter
88 tweeters
patent
13 patents
facebook
16 Facebook pages

Citations

dimensions_citation
164 Dimensions

Readers on

mendeley
283 Mendeley
citeulike
1 CiteULike
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Title
The sympathetic nervous response in inflammation
Published in
Arthritis Research & Therapy, December 2014
DOI 10.1186/s13075-014-0504-2
Pubmed ID
Authors

Georg Pongratz, Rainer H Straub

Abstract

Over the past decades evidence has accumulated clearly demonstrating a pivotal role for the sympathetic nervous system (SNS) and its neurotransmitters in regulating inflammation. The first part of this review provides the reader with an overview showing that the interaction of the SNS with the immune system to control inflammation is strongly context-dependent (for example, depending on the activation state of the immune cell or neuro-transmitter concentration). In the second part we focus on autoimmune arthritis as a well investigated example for sympathetically controlled inflammation to show that the SNS and catecholamines play a differential role depending on the time point of ongoing disease. A model will be developed to explain the proinflammatory effects of the SNS in the early phase and the anti-inflammatory effects of catecholamines in the later phase of autoimmune arthritis. In the final part, a conceptual framework is discussed that shows that a major purpose of increased SNS activity is nourishment of a continuously activated immune system at a systemic level using energy-rich fuels (glucose, amino acids, lipids), while uncoupling from central nervous regulation occurs at sites of inflammation by repulsion of sympathetic fibers and local adrenoceptor regulation. This creates zones of ‘permitted local inflammation’. However, if this ‘inflammatory configuration’ persists and is strong, as in autoimmunity, the effects are detrimental because of the resultant chronic catabolic state, leading to cachexia, high blood pressure, insulin resistance, and increased cardiovascular mortality, and so on. Today, the challenge is to translate this conceptual knowledge into clinical benefit.

Twitter Demographics

The data shown below were collected from the profiles of 88 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 283 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Italy 1 <1%
Australia 1 <1%
Unknown 280 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 44 16%
Researcher 39 14%
Student > Bachelor 38 13%
Student > Master 32 11%
Other 30 11%
Other 67 24%
Unknown 33 12%
Readers by discipline Count As %
Medicine and Dentistry 80 28%
Agricultural and Biological Sciences 37 13%
Nursing and Health Professions 28 10%
Biochemistry, Genetics and Molecular Biology 26 9%
Neuroscience 25 9%
Other 41 14%
Unknown 46 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2021.
All research outputs
#509,191
of 19,545,556 outputs
Outputs from Arthritis Research & Therapy
#35
of 2,740 outputs
Outputs of similar age
#8,312
of 331,875 outputs
Outputs of similar age from Arthritis Research & Therapy
#3
of 56 outputs
Altmetric has tracked 19,545,556 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,740 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,875 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.