↓ Skip to main content

Early life environment and natural history of inflammatory bowel diseases

Overview of attention for article published in BMC Gastroenterology, December 2014
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

twitter
4 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
27 Dimensions

Readers on

mendeley
83 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Early life environment and natural history of inflammatory bowel diseases
Published in
BMC Gastroenterology, December 2014
DOI 10.1186/s12876-014-0216-8
Pubmed ID
Authors

Abra Y Guo, Betsy W Stevens, Robin G Wilson, Caitlin N Russell, Melissa A Cohen, Holly C Sturgeon, Anna Thornton, Cosmas Giallourakis, Hamed Khalili, Deanna D Nguyen, Jenny Sauk, Vijay Yajnik, Ramnik J Xavier, Ashwin N Ananthakrishnan

Abstract

BackgroundEarly life exposures may modify risk of inflammatory bowel diseases (IBD; Crohn¿s disease (CD), ulcerative colitis (UC)). However, the relationship between early life exposures and natural history of IBD has not been previously examined.MethodsThis single center study included patients with CD or UC recruited in a prospective IBD registry. Enrolled patients completed a detailed environmental questionnaire that assessed various early life environmental exposures. Our primary outcome was requirement for disease-related surgery in CD and UC. Logistic regression models defined independent effect of early life exposures, adjusting for potential confounders.ResultsOur study included 333 CD and 270 UC patients. Just over half were female with a median age at diagnosis of 25 years. One-third of the cohort had history of bowel surgery (31%) and nearly half had used at least one biologic agent (47%). Among those with CD, being breastfed was associated with reduced risk of CD-related surgery (34% vs. 55%), while childhood cigarette smoke exposure was associated with increased risk. On multivariate analysis, history of being breastfed (odds ratio (OR) 0.21, 95% confidence interval [CI] 0.09¿0.46) and cigarette smoke exposure as a child (OR 2.17, 95% CI 1.10¿4.29) remained independently associated with surgery. None of the early life variables influenced disease phenotype or outcome in UC.ConclusionA history of being breastfed was associated with a decreased risk while childhood cigarette smoke exposure was associated with an increased risk of surgery in patients with CD. Further investigation to examine biological mechanisms is warranted.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Unknown 81 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 18%
Researcher 11 13%
Student > Ph. D. Student 10 12%
Student > Doctoral Student 9 11%
Other 6 7%
Other 13 16%
Unknown 19 23%
Readers by discipline Count As %
Medicine and Dentistry 33 40%
Agricultural and Biological Sciences 9 11%
Nursing and Health Professions 9 11%
Computer Science 2 2%
Immunology and Microbiology 2 2%
Other 8 10%
Unknown 20 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2014.
All research outputs
#9,000,500
of 16,578,610 outputs
Outputs from BMC Gastroenterology
#372
of 1,084 outputs
Outputs of similar age
#106,477
of 272,449 outputs
Outputs of similar age from BMC Gastroenterology
#40
of 124 outputs
Altmetric has tracked 16,578,610 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,084 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,449 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.