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Polymorphisms in the feline TNFA and CD209 genes are associated with the outcome of feline coronavirus infection

Overview of attention for article published in Veterinary Research, December 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

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4 tweeters

Citations

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14 Dimensions

Readers on

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42 Mendeley
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Title
Polymorphisms in the feline TNFA and CD209 genes are associated with the outcome of feline coronavirus infection
Published in
Veterinary Research, December 2014
DOI 10.1186/s13567-014-0123-6
Pubmed ID
Authors

Ying-Ting Wang, Li-En Hsieh, Yu-Rou Dai, Ling-Ling Chueh

Abstract

Feline infectious peritonitis (FIP), caused by feline coronavirus (FCoV) infection, is a highly lethal disease without effective therapy and prevention. With an immune-mediated disease entity, host genetic variant was suggested to influence the occurrence of FIP. This study aimed at evaluating cytokine-associated single nucleotide polymorphisms (SNPs), i.e., tumor necrosis factor alpha (TNF-α), receptor-associated SNPs, i.e., C-type lectin DC-SIGN (CD209), and the five FIP-associated SNPs identified from Birman cats of USA and Denmark origins and their associations with the outcome of FCoV infection in 71 FIP cats and 93 FCoV infected non-FIP cats in a genetically more diverse cat populations. A promoter variant, fTNFA - 421 T, was found to be a disease-resistance allele. One SNP was identified in the extracellular domain (ECD) of fCD209 at position +1900, a G to A substitution, and the A allele was associated with FIP susceptibility. Three SNPs located in the introns of fCD209, at positions +2276, +2392, and +2713, were identified to be associated with the outcome of FCoV infection, with statistical relevance. In contrast, among the five Birman FIP cat-associated SNPs, no genotype or allele showed significant differences between our FIP and non-FIP groups. As disease resistance is multifactorial and several other host genes could involve in the development of FIP, the five genetic traits identified in this study should facilitate in the future breeding of the disease-resistant animal to reduce the occurrence of cats succumbing to FIP.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 17%
Researcher 7 17%
Student > Master 7 17%
Student > Bachelor 6 14%
Student > Doctoral Student 2 5%
Other 7 17%
Unknown 6 14%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 9 21%
Biochemistry, Genetics and Molecular Biology 6 14%
Agricultural and Biological Sciences 5 12%
Immunology and Microbiology 3 7%
Medicine and Dentistry 2 5%
Other 6 14%
Unknown 11 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2014.
All research outputs
#11,764,795
of 20,269,949 outputs
Outputs from Veterinary Research
#539
of 1,097 outputs
Outputs of similar age
#136,922
of 297,109 outputs
Outputs of similar age from Veterinary Research
#27
of 79 outputs
Altmetric has tracked 20,269,949 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,097 research outputs from this source. They receive a mean Attention Score of 4.5. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,109 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.