Title |
Ibuprofen versus mecillinam for uncomplicated cystitis - a randomized controlled trial study protocol
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Published in |
BMC Infectious Diseases, December 2014
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DOI | 10.1186/s12879-014-0693-y |
Pubmed ID | |
Authors |
Ingvild Vik, Marianne Bollestad, Nils Grude, Anders Bærheim, Sigvard Mölstad, Lars Bjerrum, Morten Lindbæk |
Abstract |
BackgroundAlthough uncomplicated cystitis is often self-limiting, most such patients will be prescribed antibiotic treatment. We are investigating whether treatment of cystitis with an NSAID is as effective as an antibiotic in achieving symptomatic resolution.Methods/DesignThis is a randomized, controlled, double blind trial following the principles of Good Clinical Practice. Women between the ages of 18 to 60 presenting with symptoms of uncomplicated cystitis are screened for eligibility. 500 women from four sites in Norway, Sweden and Denmark are allocated to treatment with 600 mg ibuprofen three times a day or 200 mg mecillinam three times a day for three days. Allocation is conducted using block randomization. The primary outcome is the number of patients who feel cured by day four as recorded in a diary. Adverse events will be handled and reported in accordance with Good Clinical Practice.DiscussionIf treatment of uncomplicated cystitis with ibuprofen is as effective as mecillinam for symptom relief, we can potentially reduce the use of antibiotics on a global scale.Trial registrationEudraCTnr: 2012-002776-14. ClinicalTrials.gov: NCT01849926. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 1 | 14% |
United States | 1 | 14% |
Norway | 1 | 14% |
Finland | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 11 | 23% |
Student > Master | 7 | 15% |
Student > Ph. D. Student | 6 | 13% |
Researcher | 5 | 10% |
Other | 3 | 6% |
Other | 6 | 13% |
Unknown | 10 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 50% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 10% |
Nursing and Health Professions | 2 | 4% |
Social Sciences | 2 | 4% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 3 | 6% |
Unknown | 11 | 23% |