Title |
Swimming-induced exercise promotes hypertrophy and vascularization of fast skeletal muscle fibres and activation of myogenic and angiogenic transcriptional programs in adult zebrafish
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Published in |
BMC Genomics, December 2014
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DOI | 10.1186/1471-2164-15-1136 |
Pubmed ID | |
Authors |
Arjan P Palstra, Mireia Rovira, David Rizo-Roca, Joan Ramon Torrella, Herman P Spaink, Josep V Planas |
Abstract |
The adult skeletal muscle is a plastic tissue with a remarkable ability to adapt to different levels of activity by altering its excitability, its contractile and metabolic phenotype and its mass. We previously reported on the potential of adult zebrafish as a tractable experimental model for exercise physiology, established its optimal swimming speed and showed that swimming-induced contractile activity potentiated somatic growth. Given that the underlying exercise-induced transcriptional mechanisms regulating muscle mass in vertebrates are not fully understood, here we investigated the cellular and molecular adaptive mechanisms taking place in fast skeletal muscle of adult zebrafish in response to swimming. |
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Mendeley readers
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