Title |
Functional lung avoidance for individualized radiotherapy (FLAIR): study protocol for a randomized, double-blind clinical trial
|
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Published in |
BMC Cancer, December 2014
|
DOI | 10.1186/1471-2407-14-934 |
Pubmed ID | |
Authors |
Douglas A Hoover, Dante PI Capaldi, Khadija Sheikh, David A Palma, George B Rodrigues, A Rashid Dar, Edward Yu, Brian Dingle, Mark Landis, Walter Kocha, Michael Sanatani, Mark Vincent, Jawaid Younus, Sara Kuruvilla, Stewart Gaede, Grace Parraga, Brian P Yaremko |
Abstract |
Although radiotherapy is a key component of curative-intent treatment for locally advanced, unresectable non-small cell lung cancer (NSCLC), it can be associated with substantial pulmonary toxicity in some patients. Current radiotherapy planning techniques aim to minimize the radiation dose to the lungs, without accounting for regional variations in lung function. Many patients, particularly smokers, can have substantial regional differences in pulmonary ventilation patterns, and it has been hypothesized that preferential avoidance of functional lung during radiotherapy may reduce toxicity. Although several investigators have shown that functional lung can be identified using advanced imaging techniques and/or demonstrated the feasibility and theoretical advantages of avoiding functional lung during radiotherapy, to our knowledge this premise has never been tested via a prospective randomized clinical trial. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 105 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 25 | 24% |
Student > Ph. D. Student | 11 | 10% |
Other | 8 | 8% |
Researcher | 6 | 6% |
Student > Postgraduate | 5 | 5% |
Other | 21 | 20% |
Unknown | 29 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 28% |
Nursing and Health Professions | 13 | 12% |
Physics and Astronomy | 8 | 8% |
Business, Management and Accounting | 5 | 5% |
Computer Science | 4 | 4% |
Other | 14 | 13% |
Unknown | 32 | 30% |