Title |
Sunitinib-induced severe toxicities in a Japanese patient with the ABCG2 421 AA genotype
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Published in |
BMC Cancer, December 2014
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DOI | 10.1186/1471-2407-14-964 |
Pubmed ID | |
Authors |
Yuji Miura, Chiyo K Imamura, Koya Fukunaga, Yoshihiko Katsuyama, Koichi Suyama, Toshikazu Okaneya, Taisei Mushiroda, Yuichi Ando, Toshimi Takano, Yusuke Tanigawara |
Abstract |
Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor that acts against receptors for vascular endothelial growth factor and platelet-derived growth factor. Common toxicities of sunitinib treatment include hypertension, hand-foot syndrome, vomiting, and diarrhea, and the proportion of grade 3 or 4 adverse events relating to sunitinib treatment range from 1 to 13% for all categories. It is reported that increased exposure to sunitinib is associated with improved clinical outcomes but also carries an increased risk of adverse effects. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 16% |
Student > Master | 7 | 16% |
Student > Ph. D. Student | 3 | 7% |
Student > Doctoral Student | 3 | 7% |
Professor | 2 | 4% |
Other | 10 | 22% |
Unknown | 13 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Agricultural and Biological Sciences | 3 | 7% |
Nursing and Health Professions | 3 | 7% |
Other | 9 | 20% |
Unknown | 16 | 36% |