Title |
Computational analysis of the roles of ER-Golgi network in the cell cycle
|
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Published in |
BMC Systems Biology, December 2014
|
DOI | 10.1186/1752-0509-8-s4-s3 |
Pubmed ID | |
Authors |
Haijun Gong, Lu Feng |
Abstract |
ER-Golgi network plays an important role in the processing, sorting and transport of proteins, and it's also a site for many signaling pathways that regulate the cell cycle. Accumulating evidence suggests that, the stressed ER and malfunction of Golgi apparatus are associated with the pathogenesis of cancer and Alzheimer's disease (AD). Our previous work discovered and verified that altering the expression levels of target SNARE and GEF could modulate the size of Golgi apparatus. Moreover, Golgi's structure and size undergo dramatic changes during the development of several diseases. It is of importance to investigate the roles of ER-Golgi network in the cell cycle progression and some diseases. |
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