Title |
Recent development in clinical applications of PD-1 and PD-L1 antibodies for cancer immunotherapy
|
---|---|
Published in |
Journal of Hematology & Oncology, December 2017
|
DOI | 10.1186/s13045-017-0541-9 |
Pubmed ID | |
Authors |
Bingshan Liu, Yongping Song, Delong Liu |
Abstract |
Antibodies against programmed death (PD) pathway are revolutionizing cancer immunotherapy. Currently five antibodies against PD-1/PD-L1 have been approved. The clinical use of these antibodies is rapidly expanding. Incorporation of PD antibodies into chemotherapy regimens is in active clinical investigations. The combination of pembrolizumab with carboplatin and pemetrexed has been approved for the first line therapy of metastatic non-squamous non-small cell lung cancer. Combination of PD-1/PD-L1 antibodies with small molecule inhibitors such as tyrosine kinase inhibitors and IDO inhibitors are in active clinical trials. This review summarized recent development in clinical trials of PD-1 and PD-L1 antibodies for cancer immunotherapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 102 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 14% |
Student > Master | 13 | 13% |
Researcher | 12 | 12% |
Student > Ph. D. Student | 10 | 10% |
Other | 8 | 8% |
Other | 17 | 17% |
Unknown | 28 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 13% |
Biochemistry, Genetics and Molecular Biology | 12 | 12% |
Agricultural and Biological Sciences | 6 | 6% |
Nursing and Health Professions | 5 | 5% |
Other | 9 | 9% |
Unknown | 31 | 30% |