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Attention Score in Context
| Title |
Gene variations in oestrogen pathways, CYP19A1, daily 17β-estradiol and mammographic density phenotypes in premenopausal women
|
|---|---|
| Published in |
Breast Cancer Research, December 2014
|
| DOI | 10.1186/s13058-014-0499-2 |
| Pubmed ID | |
| Authors |
Vidar G Flote, Anne-Sofie Furberg, Anne McTiernan, Hanne Frydenberg, Giske Ursin, Anita Iversen, Trygve Lofteroed, Peter T Ellison, Erik A Wist, Thore Egeland, Tom Wilsgaard, Karen W Makar, Jenny Chang-Claude, Inger Thune |
| Abstract |
IntroductionHigh mammographic density is an established breast cancer risk factor, and circulating oestrogen influence oestrogen-regulating gene expression in breast cancer development. However, less is known about the interrelationships of common variants in the CYP19A1 gene, daily levels of oestrogens, mammographic density phenotypes, and body mass index (BMI) in premenopausal women.MethodsBased on plausible biological mechanisms related to the oestrogen pathway, we investigated the association of single nucleotide polymorphisms (SNPs) in CYP19A1, 17ß-estradiol and mammographic density in 202 premenopausal women. DNA was genotyped using the Illumina Golden Gate platform. Daily salivary 17ß-estradiol concentrations were measured throughout an entire menstrual cycle. Mammographic density phenotypes were assessed using a computer-assisted method (Madena). We determined associations using multivariable linear and logistic regression models.ResultsThe minor alleles of rs749292 were positively (P¿=¿0.026), and the minor alleles of rs7172156 were inversely (P¿=¿0.002) associated with daily 17ß-estradiol. We observed an 87% lower level of daily 17ß-estradiol throughout a menstrual cycle in heavier women (BMI >23.6 kg/m2) of rs7172156 with minor genotype aa compared with major genotype AA. Furthermore, the rs749292 minor alleles were inversely associated with absolute mammographic density (P¿=¿0.032). Lean women with rs749292 minor alleles had 70 to 80% lower risk for high absolute mammographic density (>32.4 cm2); Aa: odds ratio (OR)¿=¿0.23 (95% CI 0.07 to 0.75). Lean women with rs7172156 minor homozygous genotype had OR 5.45 for high absolute mammographic density (aa: OR¿=¿5.45 (95% CI 1.13 to 26.3)).ConclusionOur findings suggest that two SNPs in CYP19A1, rs749292 and rs7172156, are associated with both daily oestrogen levels and mammographic density phenotypes. Body mass index may modify these associations, but larger studies are needed. |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 18% |
| Student > Bachelor | 3 | 9% |
| Professor > Associate Professor | 3 | 9% |
| Student > Master | 3 | 9% |
| Student > Postgraduate | 2 | 6% |
| Other | 5 | 15% |
| Unknown | 12 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 26% |
| Biochemistry, Genetics and Molecular Biology | 4 | 12% |
| Agricultural and Biological Sciences | 3 | 9% |
| Nursing and Health Professions | 2 | 6% |
| Economics, Econometrics and Finance | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 15 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2014.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Breast Cancer Research
#1,883
of 2,053 outputs
Outputs of similar age
#307,651
of 360,183 outputs
Outputs of similar age from Breast Cancer Research
#41
of 50 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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