Title |
Immunohistochemical determination of the miR-1290 target arylamine N-acetyltransferase 1 (NAT1) as a prognostic biomarker in breast cancer
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Published in |
BMC Cancer, December 2014
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DOI | 10.1186/1471-2407-14-990 |
Pubmed ID | |
Authors |
Yumi Endo, Hiroko Yamashita, Satoru Takahashi, Shinya Sato, Nobuyasu Yoshimoto, Tomoko Asano, Yukari Hato, Yu Dong, Yoshitaka Fujii, Tatsuya Toyama |
Abstract |
There are many molecular differences between estrogen receptor α (ERα)-positive and ER-negative breast cancers. Recent analyses have shown that the former can be divided into two subtypes, luminal A and luminal B. These differ in response to endocrine therapy and chemotherapy, and in prognosis. In a previous study, we found that microRNA (miR)-1290 that was significantly down-regulated in luminal A tumors and its potential target arylamine N-acetyltransferase 1 (NAT1). The aim of the present study was to determine whether NAT1 is a bona fide target of miR-1290, and to investigate the impact of NAT1 on breast cancer prognosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 24% |
Student > Master | 5 | 13% |
Student > Doctoral Student | 4 | 11% |
Student > Bachelor | 4 | 11% |
Student > Ph. D. Student | 4 | 11% |
Other | 6 | 16% |
Unknown | 6 | 16% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 21% |
Medicine and Dentistry | 7 | 18% |
Agricultural and Biological Sciences | 6 | 16% |
Computer Science | 4 | 11% |
Environmental Science | 1 | 3% |
Other | 4 | 11% |
Unknown | 8 | 21% |