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COMT genotype and non-recovery after a whiplash injury in a Northern European population

Overview of attention for article published in BMC Musculoskeletal Disorders, December 2017
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Title
COMT genotype and non-recovery after a whiplash injury in a Northern European population
Published in
BMC Musculoskeletal Disorders, December 2017
DOI 10.1186/s12891-017-1810-z
Pubmed ID
Authors

Eric Rydman, Erika Comasco, H. Pettersson, L. Oreland, S. Ponzer, C. Ottosson

Abstract

The COMT (Catechol-O-Methyl Transferase) gene may influence a person's vulnerability to develop long-term pain and some COMT single nucleotide polymorphisms (SNPs) may associate with patterns of acute or chronic pain. Many patients with whiplash-associated disorders (WADs) suffer from long-term pain and other related symptoms, but it is less known if genetic factors play a role in the recovery process. The primary aim of this study was to evaluate whether self-reported non-recovery, including pain, was related to COMT genotype in patients with WAD. The secondary aim was to investigate whether or not background factors, including mental health, were related to genotype and non-recovery. A total of 133 patients with neck pain after a whiplash trauma were included. Background factors were collected and blood samples were taken during the acute phase after the accident. DNA was isolated from blood and used to genotype the SNPs rs6269, rs4633, rs4818 and rs4680 in the COMT gene; additionally haplotypes were estimated and haplogenotypes inferred. The patients were followed up after 12 months and asked to rate their recovery including pain, mental health and quality of life. The overall reported non-recovery rate at 12 months was 44% with no significant differences in distribution of the COMT haplotypes. High levels of self-reported pain (OR 7.2) and anxiety (OR 4.4) after the accident were associated with non-recovery, but not related to the haplotypes. None of the other background factors were related to the haplotypes or non-recovery. No association between self-reported non-recovery or pain levels and COMT haplotypes in patients with acute whiplash injuries could be detected. Independent replications are necessary to discard the hypothesis that COMT haplotypes do not influence non-recovery or pain levels in patients with acute whiplash injuries. High levels of initial pain and anxiety were associated with non-recovery, thereby confirming previously published reports.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 13%
Student > Ph. D. Student 3 8%
Researcher 3 8%
Professor > Associate Professor 3 8%
Lecturer 2 5%
Other 12 31%
Unknown 11 28%
Readers by discipline Count As %
Nursing and Health Professions 9 23%
Medicine and Dentistry 9 23%
Psychology 4 10%
Neuroscience 2 5%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 3 8%
Unknown 11 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2017.
All research outputs
#10,859,990
of 12,253,439 outputs
Outputs from BMC Musculoskeletal Disorders
#2,220
of 2,428 outputs
Outputs of similar age
#283,764
of 341,979 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#122
of 149 outputs
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