Title |
Severe persistent unremitting dermatitis, chronic diarrhea and hypoalbuminemia in a child; Hartnup disease in setting of celiac disease
|
---|---|
Published in |
BMC Pediatrics, December 2014
|
DOI | 10.1186/s12887-014-0311-6 |
Pubmed ID | |
Authors |
Thomas Ciecierega, Imad Dweikat, Mohammad Awar, Maher Shahrour, Bassam Abu Libdeh, Mutaz Sultan |
Abstract |
BackgroundCeliac disease (CD) is a complex autoimmune disorder that can lead to an inflammatory small intestinal villous atrophy and malabsorption.Hartnup disease is an autosomal recessive disorder caused by increased urinary excretion of neutral amino acids. Co-occurrence of Hartnup disease and CD is extremely rare with only a single case reported.Case reportWe report a 3-year girl with chronic diarrhea, Hypoalbuminemia and exfoliative erythema. She was diagnosed with celiac disease, which did not improve on gluten free diet. Hartnup disease was suspected and was confirmed by neutral aminoaciduria. Niacin was started and followed by dramatic improvement.ConclusionPresence of Celiac and Hartnup disease in single individual is very rare. Complete nutritional assessment of refractory celiac patient can reveal underlying nutritional deficiency. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
Saudi Arabia | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 33% |
Student > Doctoral Student | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Researcher | 2 | 13% |
Librarian | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 27% |
Biochemistry, Genetics and Molecular Biology | 3 | 20% |
Nursing and Health Professions | 2 | 13% |
Agricultural and Biological Sciences | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Other | 2 | 13% |
Unknown | 2 | 13% |