Title |
Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms
|
---|---|
Published in |
Journal of Nanobiotechnology, October 2017
|
DOI | 10.1186/s12951-017-0310-5 |
Pubmed ID | |
Authors |
Min Wei, Song Li, Weidong Le |
Abstract |
Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. The chemical and physical properties of surrounding microenvironment contribute to the growth and differentiation of stem cells and consequently play crucial roles in the regulation of stem cells' fate. Nanomaterials hold great promise in biological and biomedical fields owing to their unique properties, such as controllable particle size, facile synthesis, large surface-to-volume ratio, tunable surface chemistry, and biocompatibility. Over the recent years, accumulating evidence has shown that nanomaterials can facilitate stem cell proliferation and differentiation, and great effort is undertaken to explore their possible modulating manners and mechanisms on stem cell differentiation. In present review, we summarize recent progress in the regulating potential of various nanomaterials on stem cell differentiation and discuss the possible cell uptake, biological interaction and underlying mechanisms. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 124 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 20% |
Student > Master | 16 | 13% |
Student > Bachelor | 16 | 13% |
Researcher | 15 | 12% |
Student > Doctoral Student | 10 | 8% |
Other | 12 | 10% |
Unknown | 30 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 20 | 16% |
Materials Science | 11 | 9% |
Medicine and Dentistry | 11 | 9% |
Engineering | 10 | 8% |
Chemistry | 8 | 6% |
Other | 25 | 20% |
Unknown | 39 | 31% |