Title |
Tools for integrated sequence-structure analysis with UCSF Chimera
|
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Published in |
BMC Bioinformatics, July 2006
|
DOI | 10.1186/1471-2105-7-339 |
Pubmed ID | |
Authors |
Elaine C Meng, Eric F Pettersen, Gregory S Couch, Conrad C Huang, Thomas E Ferrin |
Abstract |
Comparing related structures and viewing the structures in the context of sequence alignments are important tasks in protein structure-function research. While many programs exist for individual aspects of such work, there is a need for interactive visualization tools that: (a) provide a deep integration of sequence and structure, far beyond mapping where a sequence region falls in the structure and vice versa; (b) facilitate changing data of one type based on the other (for example, using only sequence-conserved residues to match structures, or adjusting a sequence alignment based on spatial fit); (c) can be used with a researcher's own data, including arbitrary sequence alignments and annotations, closely or distantly related sets of proteins, etc.; and (d) interoperate with each other and with a full complement of molecular graphics features. We describe enhancements to UCSF Chimera to achieve these goals. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 1% |
Australia | 2 | <1% |
United Kingdom | 2 | <1% |
France | 1 | <1% |
South Africa | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 393 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 74 | 18% |
Researcher | 55 | 14% |
Student > Bachelor | 41 | 10% |
Student > Master | 37 | 9% |
Student > Doctoral Student | 25 | 6% |
Other | 76 | 19% |
Unknown | 99 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 125 | 31% |
Agricultural and Biological Sciences | 79 | 19% |
Chemistry | 42 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 3% |
Computer Science | 10 | 2% |
Other | 33 | 8% |
Unknown | 105 | 26% |