Title |
The association of N-terminal pro-brain-type natriuretic peptide with hemodynamics and functional capacity in therapy-naive precapillary pulmonary hypertension: results from a cohort study
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Published in |
BMC Pulmonary Medicine, December 2017
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DOI | 10.1186/s12890-017-0521-4 |
Pubmed ID | |
Authors |
T. M. Berghaus, J. Kutsch, C. Faul, W. von Scheidt, M. Schwaiblmair |
Abstract |
N-terminal pro-brain-type natriuretic peptide (NT-proBNP) is currently used as a surrogate marker for disease severity in pulmonary hypertension (PH). However, NT-proBNP tends to have a high variability and may insufficiently correlate with hemodynamics and exercise capacity. To investigate the association of NT-proBNP with hemodynamics and cardio-pulmonary exercise testing (CPET) in 84 therapy-naive patients with precapillary PH. NT-proBNP levels were significantly correlated with hemodynamics and CPET parameters except for cardiac index, diffusion capacity, PaO2 at peak exercise, and peak minute ventilation. NT-proBNP correlated best with hemodynamics and CPET in women and patients >65 years. NT-proBNP correlated better with CPET in pulmonary arterial hypertension compared to chronic thromboembolic PH (CTEPH). NT-proBNP is associated with disease severity in precapillary PH. The association might be age- and gender-dependent. NT-proBNP may insufficiently correlate with disease severity in CTEPH, possibly due to comorbidity. |
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Members of the public | 1 | 100% |
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Researcher | 6 | 18% |
Student > Bachelor | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Student > Master | 3 | 9% |
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Other | 3 | 9% |
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Unspecified | 1 | 3% |
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Agricultural and Biological Sciences | 1 | 3% |
Other | 2 | 6% |
Unknown | 14 | 42% |