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Nucleosome positioning is unaltered at MLH1 splice site mutations in cells derived from Lynch syndrome patients

Overview of attention for article published in Clinical Epigenetics, December 2014
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2 tweeters

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Title
Nucleosome positioning is unaltered at MLH1 splice site mutations in cells derived from Lynch syndrome patients
Published in
Clinical Epigenetics, December 2014
DOI 10.1186/s13148-014-0032-6
Pubmed ID
Authors

Mathew A Sloane, Luke B Hesson, Andrea C Nunez, Bryony A Thompson, Robyn L Ward

Abstract

Splicing is more efficient when coupled with transcription and it has been proposed that nucleosomes enriched in exons are important for splice site recognition. Lynch syndrome is a familial cancer syndrome that can be caused by the autosomal dominant inheritance of splice site mutations in the MutL homolog 1 (MLH1) gene. To better understand the role of nucleosomes in splicing, we used MLH1 splice site mutations in Lynch syndrome cases as a model to investigate if abnormal splicing was associated with altered nucleosome positioning at exon-intron boundaries.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 45%
Student > Ph. D. Student 3 27%
Other 1 9%
Student > Doctoral Student 1 9%
Unknown 1 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 36%
Medicine and Dentistry 3 27%
Agricultural and Biological Sciences 1 9%
Decision Sciences 1 9%
Computer Science 1 9%
Other 0 0%
Unknown 1 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2015.
All research outputs
#2,546,434
of 4,795,986 outputs
Outputs from Clinical Epigenetics
#192
of 237 outputs
Outputs of similar age
#85,178
of 166,626 outputs
Outputs of similar age from Clinical Epigenetics
#24
of 29 outputs
Altmetric has tracked 4,795,986 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 237 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 166,626 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.