Title |
Distinct gene signatures in aortic tissue from ApoE-/-mice exposed to pathogens or Western diet
|
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Published in |
BMC Genomics, December 2014
|
DOI | 10.1186/1471-2164-15-1176 |
Pubmed ID | |
Authors |
Carolyn D Kramer, Ellen O Weinberg, Adam C Gower, Xianbao He, Samrawit Mekasha, Connie Slocum, Lea M Beaulieu, Lee Wetzler, Yuriy Alekseyev, Frank C Gibson, Jane E Freedman, Robin R Ingalls, Caroline A Genco |
Abstract |
Atherosclerosis is a progressive disease characterized by inflammation and accumulation of lipids in vascular tissue. Porphyromonas gingivalis (Pg) and Chlamydia pneumoniae (Cp) are associated with inflammatory atherosclerosis in humans. Similar to endogenous mediators arising from excessive dietary lipids, these Gram-negative pathogens are pro-atherogenic in animal models, although the specific inflammatory/atherogenic pathways induced by these stimuli are not well defined. In this study, we identified gene expression profiles that characterize P. gingivalis, C. pneumoniae, and Western diet (WD) at acute and chronic time points in aortas of Apolipoprotein E (ApoE-/-) mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
United States | 1 | 33% |
Sweden | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 18% |
Researcher | 3 | 14% |
Other | 2 | 9% |
Student > Doctoral Student | 2 | 9% |
Student > Master | 2 | 9% |
Other | 6 | 27% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 23% |
Agricultural and Biological Sciences | 4 | 18% |
Immunology and Microbiology | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Unspecified | 1 | 5% |
Other | 4 | 18% |
Unknown | 3 | 14% |