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Use of FDG-PET to guide dose prescription heterogeneity in stereotactic body radiation therapy for lung cancers with volumetric modulated arc therapy: a feasibility study

Overview of attention for article published in Radiation Oncology, December 2014
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Title
Use of FDG-PET to guide dose prescription heterogeneity in stereotactic body radiation therapy for lung cancers with volumetric modulated arc therapy: a feasibility study
Published in
Radiation Oncology, December 2014
DOI 10.1186/s13014-014-0300-9
Pubmed ID
Authors

Bénédicte Henriques de Figueiredo, Mikael Antoine, Renaud Trouette, Philippe Lagarde, Adeline Petit, Frédéric Lamare, Mathieu Hatt, Philippe Fernandez

Abstract

BackgroundThe aim of this study was to assess if FDG-PET could guide dose prescription heterogeneity and decrease arbitrary location of hotspots in SBRT.MethodsFor three patients with stage I lung cancer, a CT-simulation and a FDG-PET were registered to define respectively the PTVCT and the biological target volume (BTV). Two plans involving volumetric modulated arc therapy (VMAT) and simultaneous integrated boost (SIB) were calculated. The first plan delivered 4 × 12Gy within the PTVCT and the second plan, with SIB, 4 × 12Gy and 13.8Gy (115% of the prescribed dose) within the PTVCT and the BTV respectively. The Dmax-PTVCT had to be inferior to 60Gy (125% of the prescribed dose). Plans were evaluated through the D95%, D99% and Dmax-PTVCT, the D2cm, the R50% and R100% and the dice similarity coefficient (DSC) between the isodose 115% and BTV. DSC allows verifying the location of the 115% isodose (ideal value¿=¿1).ResultsThe mean PTVCT and BTV were 36.7 (±12.5) and 6.5 (±2.2) cm3 respectively. Both plans led to similar target coverage, same doses to the OARs and equivalent fall-off of the dose outside the PTVCT. On the other hand, the location of hotspots, evaluated through the DSC, was improved for the SIB plans with a mean DSC of 0.31 and 0.45 for the first and the second plans respectively.ConclusionsUse of PET to decrease arbitrary location of hotspots is feasible with VMAT and SIB for lung cancer.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 19%
Student > Bachelor 3 14%
Student > Postgraduate 3 14%
Professor 2 10%
Student > Master 2 10%
Other 4 19%
Unknown 3 14%
Readers by discipline Count As %
Medicine and Dentistry 10 48%
Nursing and Health Professions 3 14%
Physics and Astronomy 2 10%
Social Sciences 1 5%
Computer Science 1 5%
Other 0 0%
Unknown 4 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2015.
All research outputs
#13,926,043
of 22,775,504 outputs
Outputs from Radiation Oncology
#745
of 2,050 outputs
Outputs of similar age
#181,087
of 352,836 outputs
Outputs of similar age from Radiation Oncology
#26
of 86 outputs
Altmetric has tracked 22,775,504 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,050 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,836 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.