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Novel high dose rate lip brachytherapy technique to improve dose homogeneity and reduce toxicity by customized mold

Overview of attention for article published in Radiation Oncology, December 2014
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Title
Novel high dose rate lip brachytherapy technique to improve dose homogeneity and reduce toxicity by customized mold
Published in
Radiation Oncology, December 2014
DOI 10.1186/s13014-014-0271-x
Pubmed ID
Authors

Jon Feldman, Limor Appelbaum, Mordechay Sela, Ninel Voskoboinik, Sarit Kadouri, Jeffrey Weinberger, Itzhak Orion, Amichay Meirovitz

Abstract

Purpose/ObjectivesThe purpose of this study is to describe a novel brachytherapy technique for lip Squamous Cell Carcinoma, utilizing a customized mold with embedded brachytherapy sleeves, which separates the lip from the mandible, and improves dose homogeneity.Materials and methodsSeven patients with T2 lip cancer treated with a ¿sandwich¿ technique of High Dose Rate (HDR) brachytherapy to the lip, consisting of interstitial catheters and a customized mold with embedded catheters, were reviewed for dosimetry and outcome using 3D planning. Dosimetric comparison was made between the ¿sandwich¿ technique to ¿classic¿ ¿ interstitial catheters only plan. We compared dose volume histograms for Clinical Tumor Volume (CTV), normal tissue ¿hot spots¿ and mandible dose. We are reporting according to the ICRU 58 and calculated the Conformal Index (COIN) to show the advantage of our technique.ResultsThe seven patients (ages 36¿81 years, male) had median follow-up of 47 months. Four patients received Brachytherapy and External Beam Radiation Therapy, 3 patients received brachytherapy alone. All achieved local control, with excellent esthetic and functional results. All patients are disease free.The Customized Mold Sandwich technique (CMS) reduced the high dose region receiving 150% (V150) by an average of 20% (range 1¿47%), The low dose region (les then 90% of the prescribed dose) improved by 73% in average by using the CMS technique. The COIN value for the CMS was in average 0.92 as opposed to 0.88 for the interstitial catheter only. All differences (excluding the low dose region) were statistically significant.ConclusionThe CMS technique significantly reduces the high dose volume and increases treatment homogeneity. This may reduce the potential toxicity to the lip and adjacent mandible, and results in excellent tumor control, cosmetic and functionality.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 17%
Student > Doctoral Student 3 13%
Student > Ph. D. Student 3 13%
Student > Master 3 13%
Unspecified 2 9%
Other 4 17%
Unknown 4 17%
Readers by discipline Count As %
Medicine and Dentistry 11 48%
Unspecified 2 9%
Business, Management and Accounting 1 4%
Psychology 1 4%
Nursing and Health Professions 1 4%
Other 2 9%
Unknown 5 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 December 2014.
All research outputs
#18,387,239
of 22,775,504 outputs
Outputs from Radiation Oncology
#1,409
of 2,050 outputs
Outputs of similar age
#255,548
of 352,836 outputs
Outputs of similar age from Radiation Oncology
#54
of 86 outputs
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