↓ Skip to main content

Human oral cells’ response to different endodontic restorative materials: an in vitro study

Overview of attention for article published in Head & Face Medicine, December 2014
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
23 Dimensions

Readers on

mendeley
41 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Human oral cells’ response to different endodontic restorative materials: an in vitro study
Published in
Head & Face Medicine, December 2014
DOI 10.1186/s13005-014-0055-4
Pubmed ID
Authors

Susanne Jung, Jana Mielert, Johannes Kleinheinz, Till Dammaschke

Abstract

IntroductionThe aim of this study was to compare the biological interaction of human osteoblasts and cells of the human periodontal ligament (PDL) with different endodontic restorative material as Mineral Trioxide Aggregate (MTA), Biodentine, amalgam and composite over a time period of 20 days.Materials and methodsHuman PDL cells and osteoblasts were harvested, cultured and according to standardized protocols. The cell populations were characterized with the corresponding surface markers following standardized procedures. The specimens were produced with special regard to constant dimensions and volume in the different groups. Cell attachment and proliferation were evaluated morphologically after Richardson staining and cell count was performed after 1d, 8d, 13d and 20d. All experiments were performed in triplets. The results were statistically analyzed using the ANOVA- and Tukey-test (p¿<¿0.05).ResultsMorphological analysis proved good proliferation and cell attachment in both cements. A remarkable result was the organized spreading and parallel alignment of the PDL cells in contact with MTA and especially Biodentine (cells maturing in a second cell layer crossway to the first one). From 8d onward Biodentine showed the highest quantity of PDL cells (p¿<¿0.05). Biodentine and MTA resulted in a significantly higher cell density in osteoblast and PDL cell culture. The other groups showed a lower PDL cell density from 8d and a lower osteoblast cell density from 13d when compared to control and cement samples (p¿<¿0.05).ConclusionsMTA and Biodentine showed a good biocompatibility in contact with the human osteoblasts and cells of the periodontal ligament. Regarding cell survival and proliferation particularly of PDL cells Biodentine showed good results and can be considered as a well-tolerated bioactive endodontic material.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 6 15%
Student > Ph. D. Student 6 15%
Student > Doctoral Student 4 10%
Professor 3 7%
Student > Bachelor 3 7%
Other 12 29%
Unknown 7 17%
Readers by discipline Count As %
Medicine and Dentistry 27 66%
Agricultural and Biological Sciences 2 5%
Immunology and Microbiology 2 5%
Nursing and Health Professions 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 0 0%
Unknown 8 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 December 2014.
All research outputs
#6,003,866
of 7,918,051 outputs
Outputs from Head & Face Medicine
#105
of 203 outputs
Outputs of similar age
#157,784
of 239,414 outputs
Outputs of similar age from Head & Face Medicine
#7
of 13 outputs
Altmetric has tracked 7,918,051 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 203 research outputs from this source. They receive a mean Attention Score of 1.6. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,414 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.