Title |
Independent component analysis of Alzheimer's DNA microarray gene expression data
|
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Published in |
Molecular Neurodegeneration, January 2009
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DOI | 10.1186/1750-1326-4-5 |
Pubmed ID | |
Authors |
Wei Kong, Xiaoyang Mou, Qingzhong Liu, Zhongxue Chen, Charles R Vanderburg, Jack T Rogers, Xudong Huang |
Abstract |
Gene microarray technology is an effective tool to investigate the simultaneous activity of multiple cellular pathways from hundreds to thousands of genes. However, because data in the colossal amounts generated by DNA microarray technology are usually complex, noisy, high-dimensional, and often hindered by low statistical power, their exploitation is difficult. To overcome these problems, two kinds of unsupervised analysis methods for microarray data: principal component analysis (PCA) and independent component analysis (ICA) have been developed to accomplish the task. PCA projects the data into a new space spanned by the principal components that are mutually orthonormal to each other. The constraint of mutual orthogonality and second-order statistics technique within PCA algorithms, however, may not be applied to the biological systems studied. Extracting and characterizing the most informative features of the biological signals, however, require higher-order statistics. |
X Demographics
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Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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Germany | 1 | 2% |
Korea, Republic of | 1 | 2% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 21% |
Student > Master | 11 | 18% |
Student > Bachelor | 4 | 7% |
Student > Doctoral Student | 2 | 3% |
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Unknown | 10 | 16% |
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Neuroscience | 4 | 7% |
Mathematics | 2 | 3% |
Other | 6 | 10% |
Unknown | 10 | 16% |