Title |
The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1β
|
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Published in |
BMC Complementary Medicine and Therapies, April 2006
|
DOI | 10.1186/1472-6882-6-13 |
Pubmed ID | |
Authors |
Mark JS Miller, Salahuddin Ahmed, Paul Bobrowski, Tariq M Haqqi |
Abstract |
Cartilage loss is a hallmark of arthritis and follows activation of catabolic processes concomitant with a disruption of anabolic pathways like insulin-like growth factor 1 (IGF-1). We hypothesized that two natural products of South American origin, would limit cartilage degradation by respectively suppressing catabolism and activating local IGF-1 anabolic pathways. One extract, derived from cat's claw (Uncaria guianensis, vincaria), is a well-described inhibitor of NF-kappaB. The other extract, derived from the vegetable Lepidium meyenii (RNI 249), possessed an uncertain mechanism of action but with defined ethnomedical applications for fertility and vitality. |
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Mendeley readers
Geographical breakdown
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Student > Master | 8 | 12% |
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Professor | 4 | 6% |
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