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The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1β

Overview of attention for article published in BMC Complementary Medicine and Therapies, April 2006
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
9 X users
facebook
2 Facebook pages
googleplus
1 Google+ user

Citations

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25 Dimensions

Readers on

mendeley
66 Mendeley
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Title
The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1β
Published in
BMC Complementary Medicine and Therapies, April 2006
DOI 10.1186/1472-6882-6-13
Pubmed ID
Authors

Mark JS Miller, Salahuddin Ahmed, Paul Bobrowski, Tariq M Haqqi

Abstract

Cartilage loss is a hallmark of arthritis and follows activation of catabolic processes concomitant with a disruption of anabolic pathways like insulin-like growth factor 1 (IGF-1). We hypothesized that two natural products of South American origin, would limit cartilage degradation by respectively suppressing catabolism and activating local IGF-1 anabolic pathways. One extract, derived from cat's claw (Uncaria guianensis, vincaria), is a well-described inhibitor of NF-kappaB. The other extract, derived from the vegetable Lepidium meyenii (RNI 249), possessed an uncertain mechanism of action but with defined ethnomedical applications for fertility and vitality.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 2%
Unknown 65 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 17%
Student > Master 8 12%
Student > Ph. D. Student 6 9%
Student > Doctoral Student 5 8%
Professor 4 6%
Other 16 24%
Unknown 16 24%
Readers by discipline Count As %
Medicine and Dentistry 15 23%
Agricultural and Biological Sciences 15 23%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Biochemistry, Genetics and Molecular Biology 3 5%
Chemistry 2 3%
Other 7 11%
Unknown 19 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2017.
All research outputs
#5,081,319
of 24,943,708 outputs
Outputs from BMC Complementary Medicine and Therapies
#926
of 3,904 outputs
Outputs of similar age
#13,885
of 77,954 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#5
of 8 outputs
Altmetric has tracked 24,943,708 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,904 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 77,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.