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Mendeley readers
Attention Score in Context
| Title |
Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake
|
|---|---|
| Published in |
Journal of Nanobiotechnology, December 2014
|
| DOI | 10.1186/s12951-014-0059-z |
| Pubmed ID | |
| Authors |
David C Kennedy, Guillermo Orts-Gil, Chian-Hui Lai, Larissa Müller, Andrea Haase, Andreas Luch, Peter H Seeberger |
| Abstract |
BackgroundIncreasing use of silver nanoparticles (Ag-NPs) in various products is resulting in a greater likelihood of human exposure to these materials. Nevertheless, little is still known about the influence of carbohydrates on the toxicity and cellular uptake of nanoparticles.MethodsAg-NPs that functionalized with three different monosaccharides and ethylene glycol were synthesized and characterised. Oxidative stress and toxicity was evaluated by protein carbonylation and MTT assay, respectively. Cellular uptake was evaluated by confocal microscopy and ICP-MS.ResultsAg-NPs coated with galactose and mannose are considerably less toxic to neuronal-like cells and hepatocytes compared to particles functionalized by glucose, ethylene glycol or citrate. Toxicity correlated to oxidative stress but not to cellular uptake.ConclusionsCarbohydrate coating on silver nanoparticles modulates both oxidative stress and cellular uptake, but mainly the first has an impact on toxicity. These findings provide new perspectives on modulating the bioactivity of Ag-NPs by using carbohydrates. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Ecuador | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 2 | 1% |
| India | 1 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 133 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 25% |
| Student > Master | 20 | 14% |
| Student > Bachelor | 12 | 9% |
| Researcher | 12 | 9% |
| Student > Doctoral Student | 7 | 5% |
| Other | 20 | 14% |
| Unknown | 33 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 23 | 17% |
| Biochemistry, Genetics and Molecular Biology | 17 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 9% |
| Materials Science | 13 | 9% |
| Agricultural and Biological Sciences | 12 | 9% |
| Other | 21 | 15% |
| Unknown | 40 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 51. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2017.
All research outputs
#695,225
of 22,775,504 outputs
Outputs from Journal of Nanobiotechnology
#17
of 1,404 outputs
Outputs of similar age
#9,807
of 353,125 outputs
Outputs of similar age from Journal of Nanobiotechnology
#2
of 16 outputs
Altmetric has tracked 22,775,504 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,404 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,125 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.