You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Decreased expression of microRNA-126 is associated with poor prognosis in patients with cervical cancer
|
|---|---|
| Published in |
Diagnostic Pathology, December 2014
|
| DOI | 10.1186/s13000-014-0220-x |
| Pubmed ID | |
| Authors |
Yao Yang, Kun-ling Song, Hong Chang, Long Chen |
| Abstract |
BackgroundMicroRNA-126(miR-126) has been shown to be frequently down-regulated in a variety of malignancies and act as a potential tumor suppressor. However, its correlations with the clinicopathological characters of cervical cancer remain unclear.MethodsTaqMan quantitative RT-PCR was used to determine the expression level of miR-126 in tissue samples. The associations of miR-126 expression with clinicopathologic variables were analyzed. Kaplan-Meier survival analysis was performed to analyze the association of miR-126 expression with overall survival (OS) of patients. Univariate and multivariate Cox regression analyses were performedResultsmiR-126 expression level in human cervical cancer tissues was significantly lower than that in adjacent nontumorous tissues (mean¿±¿SD: 0.59¿±¿0.44 vs. 1.00¿±¿0.51, P¿<¿0.0001). Decreased miR-126 expression in cervical cancer was found to be significantly associated with lymphatic invasion (P¿=¿0.002), distant metastasis (P¿<¿0.001), FIGO stage (P¿=¿0.009), and histological grade (P¿=¿0.005). Kaplan-Meier analysis showed that patients with lower levels of miR-126 had significantly poorer survival than those with higher expression of this miRNA in patients, with a 5-year OS of 45.7% and 70.9%, respectively (P¿=¿0.002). Multivariate analysis revealed that miR-126 expression (HR¿=¿3.97, 95% CI: 2.01-20.22; P¿=¿0.003) was independently associated with the OS.ConclusionOur data suggests the potential of miR-126 as a prognostic biomarker for cervical cancer.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_220. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 22% |
| Student > Master | 6 | 16% |
| Student > Bachelor | 5 | 14% |
| Student > Ph. D. Student | 4 | 11% |
| Lecturer | 3 | 8% |
| Other | 5 | 14% |
| Unknown | 6 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 22% |
| Medicine and Dentistry | 8 | 22% |
| Agricultural and Biological Sciences | 6 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
| Computer Science | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 8 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2015.
All research outputs
#12,714,958
of 22,775,504 outputs
Outputs from Diagnostic Pathology
#294
of 1,123 outputs
Outputs of similar age
#160,893
of 352,205 outputs
Outputs of similar age from Diagnostic Pathology
#9
of 42 outputs
Altmetric has tracked 22,775,504 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,123 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,205 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.