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Identification of VP1 peptides diagnostic of encephalomyocarditis virus from swine

Overview of attention for article published in Virology Journal, December 2014
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Title
Identification of VP1 peptides diagnostic of encephalomyocarditis virus from swine
Published in
Virology Journal, December 2014
DOI 10.1186/s12985-014-0226-8
Pubmed ID
Authors

Juan Bai, Xinhui Chen, Kangfu Jiang, Basit Zeshan, Ping Jiang

Abstract

BackgroundEncephalomyocarditis virus (EMCV) can cause myocarditis, respiratory failure, reproductive failure, and sudden death in pre-weaned piglets, which has been isolated in China. EMCV VP1 protein was one of the most important structural proteins and played an important role in the protective immunity. In this study, 10 monoclonal antibodies (McAbs) against EMCV VP1 were screened and identified.ResultsEpitope mapping results indicated that McAbs (6E11, 7A7, 7C9) specifically recognized the linear epitopes V(2)ENAEK(7), McAbs (1D1, 2A2, 5A1, 5A11, 5G1) recognized the epitope F(19)VAQPVY(25), and McAbs 1G8 and 3A9 recognized P(42)IGAFTVK(49). Protein sequence alignment of VP1 with 16 EMCV isolates indicated that the epitope F(19)VAQPVY(25) was conserved in all the reference strains. The epitopes P(42)IGAFTVK(49) and V(2)ENAEK(7) only had 1 or 2 variable amino acid among the reference strains. The 3D model analysis results showed that these epitopes presented as spheres were shown within the context of the complete particle.ConclusionsIn this study, ten McAbs against EMCV VP1 were developed and three B-cells epitopes (2-7aa, 19-25aa and 42-49aa) were defined in VP1. All the results herein will promote the future investigations into the function of VP1 of EMCV and development of diagnostic methods of EMCV.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 22%
Student > Master 3 17%
Researcher 2 11%
Student > Ph. D. Student 2 11%
Student > Doctoral Student 1 6%
Other 3 17%
Unknown 3 17%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 4 22%
Agricultural and Biological Sciences 4 22%
Medicine and Dentistry 2 11%
Chemical Engineering 1 6%
Mathematics 1 6%
Other 3 17%
Unknown 3 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2015.
All research outputs
#3,088,006
of 4,742,359 outputs
Outputs from Virology Journal
#888
of 1,310 outputs
Outputs of similar age
#100,214
of 157,374 outputs
Outputs of similar age from Virology Journal
#64
of 69 outputs
Altmetric has tracked 4,742,359 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,310 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
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We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.