Title |
The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis
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Published in |
BMC Genomics, December 2014
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DOI | 10.1186/1471-2164-15-1179 |
Pubmed ID | |
Authors |
Kate J Howell, Lucy A Weinert, Roy R Chaudhuri, Shi-Lu Luan, Sarah E Peters, Jukka Corander, David Harris, Øystein Angen, Virginia Aragon, Albert Bensaid, Susanna M Williamson, Julian Parkhill, Paul R Langford, Andrew N Rycroft, Brendan W Wren, Matthew T G Holden, Alexander W Tucker, Duncan J Maskell |
Abstract |
Haemophilus parasuis is the etiologic agent of Glasser's disease in pigs and causes devastating losses to the farming industry. Whilst some hyper-virulent isolates have been described, the relationship between genetics and disease outcome has been only partially established. In particular, there is weak correlation between serovar and disease phenotype. We sequenced the genomes of 212 isolates of H. parasuis and have used this to describe the pan-genome and to correlate this with clinical and carrier status, as well as with serotype. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | 1% |
France | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 72 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 19% |
Researcher | 14 | 19% |
Student > Ph. D. Student | 10 | 13% |
Student > Doctoral Student | 7 | 9% |
Student > Bachelor | 6 | 8% |
Other | 9 | 12% |
Unknown | 15 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 31% |
Biochemistry, Genetics and Molecular Biology | 11 | 15% |
Veterinary Science and Veterinary Medicine | 7 | 9% |
Medicine and Dentistry | 7 | 9% |
Immunology and Microbiology | 5 | 7% |
Other | 6 | 8% |
Unknown | 16 | 21% |